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Use of a Multidrug Pill In Reducing cv Events

Objective

Cardiovascular disease is the focus of this proposal as it is the leading cause of mortality worldwide. People with established vascular disease represent a target for secondary prevention using combination therapy that addresses multiple risk factors. Barriers to effective delivery of proven secondary preventative treatments create important gaps in the uptake. These gaps vary in different countries. Complexity and cost of treatment confer particularly difficult barriers; typically an individual recovering from a stroke or heart attack might be advised to take multiple medications to address cholesterol, blood pressure and platelet function. A combination once daily polypill may address these issues. Such a pill, the Red Heart Pill, has been formulated by Dr Reddy’s Laboratories in India. It is remarkably inexpensive with a projected annual cost in India of about €15. Evidence of safety and efficacy of this low-cost fixed-dose, once-daily polypill derived from a carefully conducted clinical trial will support its use in resource-poor countries and internationally. This project aims to evaluate whether provision of a cardiovascular polypill compared with usual medications improves adherence to therapies and clinical outcomes among high-risk patients. Further aims are to measure prescription of combination therapy, barriers to adherence, quality of life, safety, cardiovascular events, and healthcare resource consumption. The results will be used to develop recommendations for equitable access relevant to both Europe and India. India has been chosen as an ICPC partner as it is the home of a large global generic pharmaceutical company – Dr Reddy’s – and about 1 in 4 heart attacks globally occur in India. Parallel polypill projects running in Australia and New Zealand will afford the opportunity of pooling data to assess effects on cardiovascular outcomes. This synergy will enhance the generalisable impact of the UMPIRE trial.

Field of science

  • /medical and health sciences/clinical medicine/angiology/vascular diseases
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 969 149
Administrative Contact
Tatjana Palalic (Ms.)

Participants (7)

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
EU contribution
€ 502 072
Address
Saint Stephen's Green 123
2 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Barbara Gallagher (Ms.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 501 602
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne/Marie Laeven (Dr.)
George Institute for Global Health
India
EU contribution
€ 413 628,43
Address
Plot No.839c, Road No. 44A, Jubilee Hills
500033 Hyderabad
Activity type
Research Organisations
Administrative Contact
A. Sunder Rajan (Dr.)
PUBLIC HEALTH FOUNDATION OF INDIA
India
EU contribution
€ 17 600
Address
Isid Campus, 4Th Institutional Area, Vasant Kunj
110070 New Delhi
Activity type
Research Organisations
Administrative Contact
Palghat Krishnan Sriraman (Mr.)
THE GEORGE INSTITUTE FOR INTERNATIONAL HEALTH LIMITED
Australia
EU contribution
€ 178 586,12
Address
Missenden Road, George V Building Royal Prince Alfred Hospital Missenden Road Camperdown Level 10
NSW 2050 Sydney
Activity type
Research Organisations
Administrative Contact
Richard Fisher (Mr.)
Dr. Reddy's Laboratories Ltd
India
Address
Ameerpet 7-1-27
500016 Hyderabad
Activity type
Research Organisations
Administrative Contact
Narasimham M V (Mr.)
CENTRE FOR CHRONIC DISEASE CONTROL SOCIETY
India
EU contribution
€ 417 228,45
Address
Vasant Kunj Tower 4 Sector C Pocket 9 Vasant Kunj
110070 New Delhi
Activity type
Research Organisations
Administrative Contact
Alex Irudayaraj (Mr.)