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NEURAL TRANSPLANTATION IN THE TREATMENT OF PATIENTS WITH PARKINSON’S DISEASE

Objetivo

There are currently no cures for Parkinson's disease (PD) but one of the most effective reparative therapies in patients to date has been with allotransplants of dopamine (DA) neuroblasts obtained from fetal ventral mesencephalic (VM) tissue. However, this cell transplantation approach has given inconsistent results, with some patients doing extremely well and coming off anti-PD medication for years, whilst others have shown no or only modest clinical improvements, and in some cases also developed severe, off-state graft-induced dyskinesias (GIDs). The reasons behind this heterogeneity of outcomes, and the emergence of GIDs in particular, need to be better understood, not least in the perspective of the rapid advances that are now being made in the development of stem-cell based therapies. There is therefore an urgent need to revisit the trials that have already been done with fetal VM tissue in PD patients, with the expectation that a critical reassessment can form the basis for an optimised and more standardised procedure that will translate into more consistently efficacious transplants with minimal side-effects. Over the last two years a group of international experts, including the key investigators of the previous European and North American trials, has been re-examining the outcome of these trials as well as reviewing the results obtained from recent and ongoing animal experimental studies, and identified a number of weaknesses that may explain the inconsistent outcome in previous trials. As a result of these discussions, the group has agreed to join forces in a new round of experimental work and cell therapy trials in PD, based on a new jointly developed protocol where all these factors are taken into account. In the first instance fetal VM tissue containing mesencephalic DA neuroblasts will be used, with the expectation that this will pave the way for bigger trials using dopaminergic neurons derived from stem cells.

Convocatoria de propuestas

FP7-HEALTH-2009-single-stage
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Coordinador

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Dirección
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Renata Schaeffer (Mr.)
Aportación de la UE
€ 3 808 371,15

Participantes (14)

MAX IV Laboratory, Lund University
Suecia
Aportación de la UE
€ 982 706,24
Dirección
Paradisgatan 5c
22100 Lund

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Higher or Secondary Education Establishments
Contacto administrativo
Anders Björklund (Prof.)
CARDIFF UNIVERSITY
United Kingdom
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€ 1 114 980
Dirección
Newport Road 30 36
CF24 0DE Cardiff

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Higher or Secondary Education Establishments
Contacto administrativo
Nick Bodycombe (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Aportación de la UE
€ 636 024,40
Dirección
South Kensington Campus Exhibition Road
SW7 2AZ London

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Higher or Secondary Education Establishments
Contacto administrativo
Mike Robinson (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
Aportación de la UE
€ 369 600
Dirección
Gower Street
WC1E 6BT London

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Greta Borg-Carbott (Ms.)
UNIVERSITAETSKLINIKUM FREIBURG
Alemania
Aportación de la UE
€ 2 005 726
Dirección
Hugstetter Strasse 49
79106 Freiburg

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Higher or Secondary Education Establishments
Contacto administrativo
Gerhard Henninger (Mr.)
LIFE SCIENCE GOVERNANCE INSTITUTE
Austria
Aportación de la UE
€ 213 664,98
Dirección
Schottenfeldgasse 29
1070 Vienna

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Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contacto administrativo
Herbert Gottweis (Prof.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Francia
Aportación de la UE
€ 756 201
Dirección
3 Avenue Victoria
75000 Paris

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Research Organisations
Contacto administrativo
Stephane Palfi (Prof.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Francia
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€ 25 849,30
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Rue De Tolbiac 101
75654 Paris

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Research Organisations
Contacto administrativo
Annick Bertault (Ms.)
DANDO WEISS & COLUCCI LIMITED

La participación finalizó

United Kingdom
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€ 310 162,14
Dirección
Lower Bristol Road Minerva House
BA2 9ER Bath

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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Isabelle Weiss (Dr.)
LIFE TECHNOLOGIES LIMITED
United Kingdom
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€ 173 600
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Fountain Drive 3
PA4 9RF Paisley

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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Alan Dion (Mr.)
Inomed Medizintechnik GmbH
Alemania
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€ 73 800
Dirección
Tullastrasse 5a
79331 Teningen

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Rudi Mattmueller (Mr.)
CAMBRIDGE COGNITION LIMITED
United Kingdom
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€ 61 650
Dirección
Tunbridge Court Tunbridge Lane, Bottisham Cambs
CB25 9TU Cambridge

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Andrew Blackwell (Dr.)
REGION SKANE
Suecia
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€ 671 759,99
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Region Skane
291 89 Kristianstad

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Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contacto administrativo
Håkan Fornander (Mr.)
IMANOVA LIMITED
United Kingdom
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€ 789 999,80
Dirección
Burlington Danes Building, Imperial College London Hammersmith Hospital, Du Cane Road
W12 0NN London

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Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Michael Cousins (Mr.)