Objective Cardiovascular disease still represents the Killer No.1 in the EU accounting for substantial morbidity/mortality and health care cost. Heart valve replacement represents the most common surgical therapy for valvular heart disease with almost 200.000 annual implantations worldwide. Currently, heart valve prosthesis-associated problems occur in 30-35% of patients within 10 years, frequently necessitating risky re-operations. A particularly severe problem relates to children with congenital heart defects (1% of all newborns) who cannot be treated efficiently due to the lack of growths of the clinically available “artificial” valve prostheses. The principal objective of the LifeValve project is to develop a new therapeutic strategy to treat heart valve disease patients more efficiently. Two novel life science technologies will be combined: tissue engineering and minimally invasive implantation technology. In particular, the scientific and technological approach of the LifeValve project is to develop a clinically relevant tissue engineered living heart valve, with the capacity of regeneration and growths which can be implanted by minimally invasive catheter technology. First clinical trials will be enrolled in paediatric patients addressing the currently unmet dramatic medical need for growing implants. A highly interdisciplinary approach combines basic sciences, medical research, engineering and clinical practice. In addition, close industry-academia collaborations are integrated. It is expected that new knowledge applicable for a much broader field of cardiovascular diseases will be generated by the unique combination of consortium partners each representing opinion leaders in their fields. The consortium is compact comprising all the necessary expertise and skills to realize the precisely planned work in a short period of time.The close collaboration of the well interconnected LifeValve consortium will most efficiently contribute to an added value for the EU. Fields of science social sciencessociologydemographymortalitymedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesmedical biotechnologyimplants Keywords Regenerative medicine cardiovascular disease heart valve tissue engineering Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-1.4-2 - Regeneration of tissue using bio-compatible materials and cells Call for proposal FP7-HEALTH-2009-single-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator University of Zurich EU contribution € 2 470 000,00 Address RAMISTRASSE 71 8006 ZURICH Switzerland See on map Activity type Higher or Secondary Education Establishments Administrative Contact Simon Philipp Hoerstrup (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all DEUTSCHES HERZZENTRUM BERLIN Germany EU contribution € 3 142 372,00 Address AUGUSTENBURGER PLATZ 1 13353 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Boris Schmitt (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNISCHE UNIVERSITEIT EINDHOVEN Netherlands EU contribution € 1 784 000,00 Address GROENE LOPER 3 5612 AE Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Higher or Secondary Education Establishments Administrative Contact Frank Baaijens (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 215 480,00 Address SPITALGASSE 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Gerald Maurer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data pfm Produkte fur die Medizin AG Germany EU contribution € 201 000,00 Address Wankelstr. 60 50996 Cologne See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jens Nikelski (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data XELTIS AG Switzerland EU contribution € 850 500,00 Address MUHLEBACHSTRASSE 26 8008 ZURICH See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact René Stenger (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data XELTIS BV Netherlands EU contribution € 1 146 000,00 Address DE LISMORTEL 31 R2 06 CAT BUILD 5612 AR Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martijn Cox (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEBRECENI EGYETEM Hungary EU contribution € 67 000,00 Address EGYETEM TER 1 4032 Debrecen See on map Region Alföld és Észak Észak-Alföld Hajdú-Bihar Activity type Higher or Secondary Education Establishments Administrative Contact Laszlo Balkay (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data