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Systems Biology of Stem Cells and Reprogramming

Objective

Stem cells are central to emerging concepts in health, medicine and therapy. The realization that specific cell reservoirs retain multipotency for tissue establishment and replenishment has implications for both the emerging field of regenerative therapy and the long standing problems of cancer, ageing and degenerative diseases. Recently the prospects for regenerative therapy have been boosted by the breakthrough finding that somatic cells can be reprogrammed into pluripotent embryonic stem (ES) cells upon expression of ES cell transcription factors. This astonishing finding further emphasizes the need to understand stem cell biology. Most of the information acquired on stem cells so far is empirical. Recent progress in systematic and computational methodologies, including seminal contributions by the applicants, permits a new approach to stem cell biology. We can now describe the systems biology of stem cells. This proposal is based on the importance of stem cells in future medicine and the need to understand the fundamental mechanisms that regulate their potential to differentiate towards specific lineages. We aim to gather the information required to understand the regulomes of key stem cells, particularly the transition between embryonic (ES) and neural (NS) cells. NS cells can be readily reprogrammed back to ES cells. We will systematically gather proteomic, transcriptomic, regulomic, live cell and cell cycle data to understand the ES – NS axis comprehensively (in both directions). We will validate the regulatory data by functional interrogation using RNAi screens and tests, complemented by quantitative fluorescent read-outs. To broaden the fundamental and medical relevance of the insights, we will pursue selected studies on other stem cells (e.g. HSCs), and their differentiated products. Thereby we will acquire a broader grasp on stem cell issues and also significantly advance mammalian systems biology.

Call for proposal

FP7-HEALTH-2009-two-stage
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Coordinator

TECHNISCHE UNIVERSITAET DRESDEN
Address
Helmholtzstrasse 10
01069 Dresden
Germany

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sven Kreigenfeld (Mr.)
EU contribution
€ 4 004 403,60

Participants (10)

DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 722 480
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kristina Holdgaard-Sørensen (Ms.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 493 440
Address
Hofgartenstrasse 8
80539 Munchen

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Activity type
Research Organisations
Administrative Contact
Birgit Knepper-Nicolai (Dr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 397 625,30
Address
Meyerhofstrasse 1
69117 Heidelberg

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Activity type
Research Organisations
Administrative Contact
Genevieve Reinke (Ms.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 860 560
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Grosveld (Prof.)
INSTITUT CURIE
France
EU contribution
€ 871 600
Address
Rue D'ulm 26
75231 Paris

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Activity type
Research Organisations
Administrative Contact
Claude Huriet (Prof.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 1 101 335,20
Address
Norregade 10
1165 Kobenhavn

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 745 280
Address
The Gibbs Building, Euston Road 215
NW1 2BE London

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Activity type
Research Organisations
Administrative Contact
David Davison (Mr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 434 200
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Cann (Mr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 542 559,50
Address
Ingolstadter Landstrasse 1
85764 Neuherberg

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Activity type
Research Organisations
Administrative Contact
Jürgen Ertel (Dr.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 356 516,40
Address
Kerpener Strasse 62
50937 Koeln

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Petra Schreiner-Kaub (Mrs.)