Objective Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and the complexity of the underlying signalling complexes pose a significant challenge to dissecting the molecular mechanisms of disease and to design efficient drugs. SynSys assembles leading European laboratories to provide the expertise and established research platforms that uniquely enable a systems-level analysis of synaptic signalling. The consortium features a closed loop from data integration and modelling, human genetics, physiology, proteomics and the application of engineered model systems to test model predictions. The main objectives of this project are to (i) provide a qualitative and quantitative description of the protein composition and the interactome of the mammalian glutamatergic synapse that integrates known human variation in these genes, (ii) to generate quantitative dynamic models describing the main functional features of the synaptic system, (iii) to reiterate on modeling by relating model predictions to synaptic function, (iv) to identify and validate, using appropriate model systems, human vulnerability genes that may form the basis of future therapies. Only a Systems level analysis can provide the means to describe synaptic transmission from molecule to function, its dynamics in relation to physiology and, brain function and brain disorders. As such, SynSys will establish a new platform for iterative molecular analysis of synapse function and dynamic modeling, with the perspective to generate a blueprint for discovery of novel pathways and targets that enable rational strategies to design therapies for human brain disease. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicinephysiologymedical and health sciencesbasic medicinemedical genetics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-2.1.2-1 - Systems biology approaches for basic biological processes relevant to health and disease Call for proposal FP7-HEALTH-2009-two-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator STICHTING VU Address De boelelaan 1105 1081 HV Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Yvonne Kops (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 2 072 800,00 Participants (17) Sort alphabetically Sort by EU Contribution Expand all Collapse all GENOME RESEARCH LIMITED Participation ended United Kingdom EU contribution € 32 043,76 Address The gibbs building, euston road 215 NW1 2BE London See on map Region London Inner London — West Camden and City of London Activity type Research Organisations Administrative Contact Seth Grant (Prof.) Links Contact the organisation Opens in new window Website Opens in new window THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 1 252 740,24 Address Old college, south bridge EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Angela Noble (Ms.) Links Contact the organisation Opens in new window Website Opens in new window MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 1 341 200,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Administrative Contact Nils Brose (Prof.) Links Contact the organisation Opens in new window Website Opens in new window MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) Germany EU contribution € 670 620,00 Address Robert rossle strasse 10 13125 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Administrative Contact Andrea Winnefeld (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution € 294 388,50 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Administrative Contact Tom Ratcliff (Mr.) Links Contact the organisation Opens in new window Website Opens in new window KOBENHAVNS UNIVERSITET Denmark EU contribution € 532 800,00 Address Norregade 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Ivan Kristoffersen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window KAROLINSKA INSTITUTET Sweden EU contribution € 529 200,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Oleg Shupliakov (Prof.) Links Contact the organisation Opens in new window Website Opens in new window CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 468 000,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Robert Preissner (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 523 200,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Administrative Contact Mihaja Auguste (Ms.) Links Contact the organisation Opens in new window Website Opens in new window VIB VZW Belgium EU contribution € 520 800,00 Address Rijvisschestraat 120 9052 Zwijnaarde - gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Administrative Contact Rik Audenaert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window HELSINGIN YLIOPISTO Finland EU contribution € 385 860,00 Address Yliopistonkatu 3 00014 Helsingin yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Administrative Contact Kaisa Ainala (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Synome Ltd United Kingdom EU contribution € 435 603,00 Address Moneta building babraham research campus CB4 1GU Cambridge See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Troels Jordansen (Mr.) Links Contact the organisation Opens in new window Brainwave-Discovery Limited United Kingdom EU contribution € 452 400,00 Address Main street ardshiel FK8 3RJ Gartmore See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Wayne Davies (Prof.) Links Contact the organisation Opens in new window Website Opens in new window BEACTICA THERAPEUTICS AB Sweden EU contribution € 444 594,00 Address Virdings alle 2 754 50 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Per Källblad (Dr.) Links Contact the organisation Opens in new window Website Opens in new window SYNAPTOLOGICS BV Netherlands EU contribution € 445 576,00 Address Achillesstraat 28 2 1008 BA Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Annemieke A. Steenbergen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window THE BABRAHAM INSTITUTE United Kingdom EU contribution € 338 011,50 Address Babraham hall CB22 3AT Cambridge See on map Region East of England East Anglia Cambridgeshire CC Administrative Contact Fang Gao (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG Participation ended Netherlands EU contribution € 0,00 Address De boelelaan 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Sander Jansen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
