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Resolution Enhanced Microscopy for Medical Diagnostics

Objective

Since the histopathological diagnosis of tumours is based on microscopy, it would be highly desirable to possess a microscopical technique allowing morphological investigation with a wide zoom range, high resolution and the implementation of multiplex staining. Thus, the goal of the REMEDI project is to explore the possibilites of novel light microscopy techniques, which overcome the diffraction limit of visible light and extend the range of observation to the molecular level of proteins in tumour cells and analyze their interaction and spatial distribution. This proposal aims at the use of single-molecule-microscopy of cancer tissue samples with ultra-high sensitivity, simplified handling and increased speed of analysis. This shall be accomplished by the development of a novel resolution-enhanced microscopy platform with an integrated novel CMOS camera and an adequate image acquistion and analysis software. The REMEDI platform will be validated with two relevant applications: diagnostic/experimental pathology of breast cancer and alterations of plasma membrane components of lymphoma cells.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /natural sciences/computer and information sciences/software
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

TILL I.D. GMBH
Address
Bahnhofstrasse 89
82166 Grafelfing
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 710 000
Administrative Contact
Stefanie Graf (Dr.)

Participants (4)

ANDOR TECHNOLOGY LIMITED
United Kingdom
EU contribution
€ 160 400
Address
Millennium Way 7 Springvale Business Park
BT12 7AL Belfast
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lynne Cross (Ms.)
GEMEINSCHAFTSPRAXIS PROF DR MED AXEL NIENDORF DR MED SYLVIA BROCKMOLLER DR MED ANNEGRET DEBUS GBR
Germany
EU contribution
€ 207 000
Address
Lornsenstrasse 4
22767 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Axel Niendorf (Prof.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 199 600
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sandy Devue-Budde (Ms.)
TILL PHOTONICS GMBH
Germany
EU contribution
€ 303 100
Address
Lochhamer Schlag 21
82166 Grafelfing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Seele (Dr.)