Objective SALIANT aims to develop a hand-held device for real-time analysis of trace levels of explosives, chemicals and drugs. The key innovation is a positive detection lateral-flow test for small molecules that is highly sensitive and simple to use making it ideally suited to deployment by First Responders at crime scenes and terrorist incidents. Lateral flow immunodiagnostics has long offered the promise of fast, high quality testing for substances of low molecular weight. There have however been very real challenges to bringing the full power of such technology to bear in this area. The problem is simply size. Large analytes can support the simultaneous binding of both capture and detector antibodies, allowing typical excess-reagent sandwich immunoassays to be formatted in which increasing analyte concentration provides an increase of observable signal over a very low zero background. Small molecules are simply not large enough to support such simultaneous binding. Alternative systems in effect measure how much analyte is not present. This causes major problems in terms of precision, sensitivity and read-out where, classically, increasing concentration of analyte reduces the signal produced, making point-of-need devices often difficult to read. What is required is a robust system in which there is no observable signal in the absence of analyte, and even low level samples give an obvious observable signal over this zero background. SALIANT offers a system based on a small bindable moiety that is first conjugated close to the binding site of a primary antibody against the analyte such that when analyte binds the antibody, the moiety can still be bound by a labelled secondary antibody. A large reagent-analogue of the analyte is also introduced, binding analyte-unbound primary antibody, and thereby blocking binding of the secondary antibody to the moiety. Thus the more analyte present, the more binding of secondary antibody occurs and the more signal is produced. Programme(s) FP7-SECURITY - Specific Programme "Cooperation": Security Topic(s) SEC-2009-1.3-04 - Advanced forensic toolbox Call for proposal FP7-SEC-2009-1 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator UNIVERSITY OF NEWCASTLE UPON TYNE EU contribution € 66 443,60 Address KINGS GATE NE1 7RU Newcastle Upon Tyne United Kingdom See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Administrative Contact Helen Gallon (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all Selective Antibodies Limited United Kingdom EU contribution € 1 184 563,20 Address CELS at Newcastle William Leech Building Framlington Place NE2 4HH Newcastle upon Tyne See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Colin Self (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data OY REAGENA Ltd Finland EU contribution € 330 534,55 Address Takojantie 18 70900 Toivala See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Markku Tuomo Olavi Parviainen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Indicia Biotechnology France EU contribution € 619 680,00 Address avenue de la Californie 33 69600 Oullins See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Stephane Legastelois (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Department of Justice, Equality & Law Reform Ireland EU contribution € 44 714,40 Address St. Stephen's Green 94 Dublin 2 Dublin See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Catriona Rainsford (Ms.) Links Contact the organisation Opens in new window Total cost No data ZILINSKA UNIVERZITA V ZILINE Slovakia EU contribution € 134 495,60 Address UNIVERZITNA 8215/1 010 26 Zilina See on map Region Slovensko Stredné Slovensko Žilinský kraj Activity type Higher or Secondary Education Establishments Administrative Contact Ladislav šimák (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Netherlands Forensic Institute Netherlands EU contribution € 177 641,25 Address Laan van Ypenburg 6 2490 AA The Hague See on map Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Marcel Van Der Steen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data METROHM-APPLIKON Netherlands EU contribution € 155 760,00 Address De Brauwweg 13 3125AE Schiedam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Timeor Frelink (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING WAGENINGEN RESEARCH Netherlands EU contribution € 407 726,00 Address DROEVENDAALSESTEEG 4 6708 PB Wageningen See on map Region Oost-Nederland Gelderland Veluwe Activity type Research Organisations Administrative Contact Ruben Van Deursen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE OF EXCELLENCE FOR LIFE SCIENCES LTD United Kingdom EU contribution € 110 640,00 Address QUORUM 16 NE12 8BX NEWCASTLE UPON TYNE See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anthea Morris (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KITE INNOVATION (EUROPE) LIMITED United Kingdom EU contribution € 130 400,00 Address 3M BUCKLEY INNOVATION CENTRE HD1 3BD Huddersfield See on map Region Yorkshire and the Humber West Yorkshire Calderdale and Kirklees Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Derek Mckenzie (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data