Objective
Bone tissue engineering is a new research area with clinical applications in the replacement of diseased or damaged bone tissues. The challenge of tissue engineering is to develop a suitable bone scaffold with sufficient porosity and mechanical strength to allow for cell adhesion, migration, growth, and proliferation, resulting in a good integration with the surrounding tissues. The aim of this project is the development and the characterisation of novel macroporous scaffolds made of ceramic/polymer composites, with controlled biodegradability, to be used for drug delivery systems in tissue engineering applications.
Our purpose is to prepare, by using different techniques, composite scaffolds made of a macroporous bioactive ceramic and a biodegradable polymer coating, which will be loaded with relevant macromolecules or growth factors. By combining biodegradability and bioactivity, optimised scaffolds for tissue engineering can be produced. Moreover, the biodegradable scaffold can be used as a controlled delivery system; in this application, the porosity controls the amount of drugs (antibiotics, antimicrobials, and growth factors) that can be incorporated.
Optimisation of the scaffold structure is essential to achieve both adequate mechanical and biological response of the composite for applications in tissue engineering. To enhance the composite - tissue biological interaction is important to obtain an interconnected porous structure of the scaffold. We will investigate the macro and microstructure of the porous composites. Moreover, we will study the mechanical, biological, and clinical response of the novel ceramic - polymer composite after contact with simulated body fluid and relevant cells. Cell culturing experiments will be carried out to assess the biological behaviour of the composites. Finally, we will investigate the dependence of the drug delivery profiles on the scaffold biodegradation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering composites
- medical and health sciences medical biotechnology tissue engineering
- engineering and technology materials engineering coating and films
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
- engineering and technology industrial biotechnology biomaterials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.