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CHEMICAL SUBSTANCE IN VITRO/IN SILICO SCREENING SYSTEM TO PREDICT HUMAN- AND ECOTOXICOLOGICAL EFFECTS

Objective

The current system of risk assessment of chemicals is complex, very resource-intensive and extremely time-consuming. Because of this, there is a great need to modernize this process. However, this is not feasible without alternative, integrated testing strategies in which chemical characteristics are used to more advantage and where costly and time consuming animal tests are replaced to a large extent by more rapid, cheap and ethically less controversial methods. This is particularly needed for reproductive toxicity testing of chemicals. Reproductive toxicity is important to assess both human and environmental toxicity and uses the most animals in toxicity testing. Unfortunately, there are very few alternative methods. ChemScreen aims to fill this gap and place the tests in a more general innovative animal-free testing strategy. For this, we will generate a simple rapid screening system, which aims at widespread implementation within the tight time schedule of the REACH program. It will be a flexible tool that can be adapted and used for applications beyond the scope of REACH and in the post-REACH period. It will use in silico methods for prescreening chemicals for all relevant toxic effects. When found positive, this will be followed by further in silico and in vitro tests, most of which are available already. To fill the gap of suitable alternative methods for reproductive toxicity testing we will use a novel high throughput approach combining in silico/in vitro methods. In this approach we will combine knowledge of critical processes affected by reproductive toxicants with knowledge on the mechanistic basis of such effects. Straightforward data interpretation and decision trees will be developed in which all information on the potential toxicity of a chemical is considered. In this way we will provide a cost-effective means to generate a basic set of data on toxicological properties of chemicals and a decision tool to assess if further testing of chemicals is required.

Call for proposal

FP7-ENV-2009-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

BioDetection Systems B.V.
Address
Science Park 406
1098 XH Amsterdam
Netherlands
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 995 904
Administrative Contact
Yvette Van Scheppingen (Ms.)

Participants (9)

PROCTER & GAMBLE EUROCOR N.V.

Participation ended

Belgium
Address
Temselaan 100
1853 Strombeek-bever
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kate Waters (Ms.)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 266 346
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Andrea Zeumann (Ms.)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Netherlands
EU contribution
€ 400 936
Address
Anna Van Buerenplein 1
2595 DA Den Haag
Activity type
Research Organisations
Administrative Contact
Dinant Kroese (Dr.)
SIMPPLE SLU
Spain
EU contribution
€ 214 656
Address
Carrer Joan Maragall 1
43003 Tarragona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Vilà Méndez (Ms.)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 385 951
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
Administrative Contact
Aldert Piersma (Prof.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 352 975
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Bay Wedebye (Ms.)
PROCTER & GAMBLE SERVICES COMPANY NV
Belgium
EU contribution
€ 286 675
Address
Temselaan 100
1853 Strombeek Bever
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kate Waters (Ms.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 293 680
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Schwarz (Prof.)
UNIVERSITAT KONSTANZ
Germany
EU contribution
€ 299 600
Address
Universitatsstrasse 10
78464 Konstanz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gertraud Plaza Pascual (Ms.)