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Development of Vaccines for bTV, EHDV and AHSV

Objective

The major outstanding challenges of orbivirus vaccine research is to develop vaccines that can afford a broad protective immune response against as many serotypes of each virus as possible, and to develop a high throughput DIVA assay (e.g. an ELISA). This project will use a coordinated multipartner approach to address these issues, to develop new experimental prototype vaccines and diagnostic approaches. It will build on specific expertise and reagents that are only available within the consortium and will link out to other international efforts in USA and South Africa to develop improved vaccines for these diseases. The consortium includes a number of industrial partners who are already active in vaccine manufacture for these and other veterinary diseases, in order to ensure that the findings of the research are transferred as soon as possible into commercial vaccines for European livestock. The project also includes two SMEs, who will be specifically involved in the development of DIVA compatible diagnostic tests. In summary, the specific objectives of the project will be: to develop multivalent vaccines using different approaches for Orbiviruses responsible for livestock diseases, in particular, Bluetongue Virus (BTV), African Horse Sickness Virus (AHSV) and Epizootic Haemorrhagic Disease Virus (EHDV); to understand the best vaccination strategy to elicit multi-serotype protection for these viruses in livestock and analyze immune responses for each of the novel vaccines developed for breadth of protection against multiple serotypes; and to develop DIVA compatible diagnostics that will work with the new vaccines developed in order to differentiate between vaccinated and infected animals.

Field of science

  • /natural sciences/biological sciences/microbiology/virology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

FP7-KBBE-2009-3
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
Address
Keppel Street
WC1E 7HT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 743 127
Administrative Contact
Greg Dow (Mr.)

Participants (17)

AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL
France
EU contribution
€ 329 250
Address
14 Rue Pierre Et Marie Curie
94700 Maisons Alfort
Activity type
Research Organisations
Administrative Contact
Foulo Basse (Mr.)
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 261 306
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maribel Rodriguez Villa (Ms.)
CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC
France
EU contribution
€ 180 000
Address
Rue Scheffer 42
75016 Paris
Activity type
Research Organisations
Administrative Contact
Jean-Marc Deboin (Mr.)
MERIAL SAS
France
EU contribution
€ 33 358
Address
Avenue Tony Garnier 29
69007 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Christophe Audonnet (Dr.)
ZOETIS MANUFACTURING & RESEARCH SPAIN SL
Spain
EU contribution
€ 168 020
Address
Ctra. De Camprodon S/n Finca 'La Riba
17813 Vall De Bianya Girona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juan Plana-Duran (Dr.)
INTERVET INTERNATIONAL BV

Participation ended

Netherlands
Address
Wim De Korverstraat 35
5831 AN Boxmeer
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Danny Goovaerts (Dr.)
BOEHRINGER INGELHEIM VETMEDICA GMBH
Germany
EU contribution
€ 5 000
Address
Binger Strasse 173
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Randolph Seidler (Dr.)
FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT
Germany
EU contribution
€ 350 000
Address
Sudufer 10
17493 Greifswald-insel Riems
Activity type
Research Organisations
Administrative Contact
Dietmar Nobis (Mr.)
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 307 500
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
Administrative Contact
Piet Van Rijn (Dr.)
DELTAMUNE (PTY) LTD
South Africa
EU contribution
€ 60 000
Address
Jean Avenue 248
0140 Lyttelton Centurion
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Maartens (Dr.)
KANSAS STATE UNIVERSITY
United States
EU contribution
€ 6 000
Address
Fairchild Hall 2
66506-1103 Manhattan Ks
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Lowe (Mr.)
THE PIRBRIGHT INSTITUTE LBG
United Kingdom
EU contribution
€ 287 168
Address
Ash Road Pirbright
GU24 0NF Woking
Activity type
Research Organisations
Administrative Contact
Keith Simpson (Mr.)
CENTRUM VOOR ONDERZOEK IN DIERGENEESKUNDE EN AGROCHEMIE - CODA
Belgium
EU contribution
€ 200 000
Address
Groeselenberg 99
1180 Bruxelles
Activity type
Research Organisations
Administrative Contact
Kris De Clercq (Dr.)
ID VET
France
EU contribution
€ 60 000
Address
Rue Pasteur 310 Zac Euromedicine Ii
34790 Grabels
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Pourquier (Mr.)
INMUNOLOGIA Y GENETICA APLICADA SA
Spain
EU contribution
€ 9 000
Address
C/ Hermanos Garcia Noblejas 41-2
28037 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eduardo Dominguez (Mr.)
AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS

Participation ended

France
Address
Avenue Du General Leclerc 27/31
94701 Maisons-alfort
Activity type
Research Organisations
Administrative Contact
Foulo Basse (Mr.)
FORT DODGE VETERINARIA, S.A.

Participation ended

Spain
Address
Ctra. Camprodon, S/n -Finca La Riba
17813 Vall De Bianya.-girona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juan Plana-Duran (Dr.)