Skip to main content

Biomimetic and Biomineralized Magnetic Nanoparticles for Magnetic Resonance Imaging

Objective

Nanoscience and nanotechnology are currently revolutionizing sectors such as medicine, information technologies, environmental or materials sciences, and creating new opportunities for our societies. In this context, magnetic nanoparticles (MNP) are key components to the development of novel nano- and biotechnologies. Magnetosomes are unique hybrid magnetic MNP produced by magnetotactic bacteria (MB). They are employed in applications ranging from extraction of DNA to the development of immunoassays and uses in spintronics are envisaged. However, only a very limited amount of MNP (few mg per day) can be formed by MB, and the formation principles remain to be tackled. Biomimetics, i.e. combining biological principles with chemistry, will pave the way to understand biomineralization of tailored MNP and to find out high-value high-yield synthetic routes to solve scientific and technological challenges. Specifically, we aspire at bridging the gap between different fields of science. For the first time, we will blend biological and genetic approaches with chemical and physical knowledge to understand the key parameters controlling the size, shape, composition and assembly of hybrid MNP in vivo and in vitro. We will combine nanoscience and nanotechnology to modify these properties and develop an ensemble of magnetic nanomaterials of higher values. This approach will lead to original contributions of innovative nature based on the combined skills of the partners to manufacture and characterize the biological, chemical, structural and magnetic properties of the MNP. The industrial partner will have key importance in managing and assessing the applicability of the MNP in Magnetic Resonance Imaging (MRI). Finally, our cell biologist partner will test the biocompatibility of the designed systems. In 3 years, we aim at being able to synthesize hybrid MNP with tailored magnetic and size properties by low-cost high-yield synthesis for applications in MRI.

Call for proposal

FP7-NMP-2009-SMALL-3
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Address
Hofgartenstrasse 8
80539 Muenchen
Germany
Activity type
Research Organisations
EU contribution
€ 605 100
Administrative Contact
Ulrike Schell (Ms.)

Participants (6)

PANNON EGYETEM
Hungary
EU contribution
€ 136 800
Address
Egyetem U 10
8200 Veszprem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mihaly Posfai (Dr.)
LATVIJAS UNIVERSITATE
Latvia
EU contribution
€ 144 720
Address
Rainis Boulevard 19
1586 Riga
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrejs Cebers (Prof.)
NANOPET PHARMA GMBH
Germany
EU contribution
€ 492 000
Address
Robert-koch-platz 4
10115 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicole Gaertner (Ms.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 291 600
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dirk Schueler (Prof.)
LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG
Austria
EU contribution
€ 100 800
Address
Nussdorfer Strasse 64/6
1090 Wien
Activity type
Research Organisations
Administrative Contact
Monika Rumpler (Dr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 228 852
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ann Marie Hirt (Prof.)