Objective
The overall objective of this proposal is to provide Dr. Gonzalez-Quevedo with an extension of her training in order to broaden her expertise and advance her scientific career. Dr. Gonzalez-Quevedo has previously used molecular biology, biochemistry and cell biology approaches to the study of cancer. She now wants to train in in vivo analyses of the normal regulation of cell migration processes during development, as this is essential for understanding mechanisms underlying its miss-regulation during tumorigenesis. Regulation of migration and adhesive properties of cells is crucial for the correct morphogenesis of developing tissues, and disruption of these processes has been implicated in cancer invasion and metastasis. Eph receptors and their ephrin ligands are critical mediators of cell migration in different contexts. Despite the increasing knowledge regarding the function of Eph receptors and ephrin, very little is known about how they are regulated to switch between adhesion and repulsion responses.
The project aims to study how FGF receptor signalling regulates Eph receptor/ephrin-mediated cell adhesion and migration. I plan to use a synergistic combination of in vitro (biochemistry, cell biology, pharmacology) and in vivo approaches (boundary formation during hindbrain segmentation in zebrafish and chick) to dissect a molecular mechanism likely to be of importance for cancer invasion and metastasis. The project contributes to the improvement of science in Europe both by addressing a fundamental mechanism of clinical relevance, and by enabling significant new training in an expert laboratory in another European country.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pharmacology and pharmacy
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.