Objective
Stem cells have the ability to both, self renew and differentiate into different cell types, what enables them to regenerate and repair tissues and organs. There are specialized niches of stem cells in the adult mammalian brain. Neural stem cells (NSC) are around blood vessels and it has been recently described that endothelial cells are able to regulate the proliferation, self-renewal and the induction of these NSC to neurons in vitro. This interplay could also result in increased angiogenesis because it h as recently been reported that NSCs are able to differenciate into endothelial cells. Moreover, the replenishment of the NSC niche with stem cells from the bone marrow can be regulated by endothelial cells. VEGF is a chemotatic cue for the migration of und ifferentiated neural progenitors, offering a mechanistic link between neurogenesis and angiogenesis in the nervous system. In the present work we will define the nature of the interactions between NSC and endothelial cells in the NSC niche, evaluating the role of the endothelium in the regulation of the NSC niche in vivo and identifying molecules involved. In order to determine whether blood vessels within the NSC niche serve as conduits for the circulating cells that replenish the niche we will determinate the fate, the origin and the mechanism of engrafted cells. Understanding the stem cell niche will provide a framework for the elucidation of stem cell function and regulation. In addition, it will provide us with valuable tools for adult stem cell therapy . The present project focuses on the role of vasculature as regulator of stem cell homeostasis and function.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine neurology stroke
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.