Objective
The major fungal pathogen, Candida albicans, has a significant impact upon the health of the European population. Candida frequently causes oral and vaginal thrush, and life-threatening infections in intensive care patients. These infections drain European finances through lost working days and extended patient hospitalization. A major goal is to understand how this fungus interacts with its human host and how these interactions contribute to pathogenesis. This will enhance efforts to develop accurate diagnostics for systemic candidiasis. Candida pathogenomics has advanced rapidly in the last decade. Nevertheless, our understanding of fungus-host interactions remains rudimentary. Therefore, our Grand Challenge is to exploit advanced new tools to accurately capture the spatial and temporal regulation of fungal molecular responses in lesions during disease progression. My laboratory is uniquely placed to address this challenge using a powerful combination of new, state-of-the-art technologies. Laser capture microscopy, ultrasensitive microarray technologies and 2D-MALDI-ToF mass spectrometry will be used to define the C. albicans transcriptome and infectome, both spatially and temporally, across fungal lesions during disease progression. C. albicans infections will be imaged with a novel ultrasensitive reporter to confirm the dynamic regulation of specific cellular processes during disease progression. Then precise molecular tools will be used to establish the relative contributions of these processes to the infection process, and to explore candidate diagnostic targets identified during this programme. This will dramatically advance our understanding of fungus-host interactions and will identify potentially novel biomarkers of deep-seated systemic candidiasis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases
- social sciences economics and business economics monetary and finances
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences genetics RNA transcriptomes
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-AdG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
AB24 3FX Aberdeen
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.