Objective
Fungal attack leads to major agricultural crop losses. Use of chemical pesticides to suppress fungal pathogens forms a threat to the environment and human health since some of these pesticides are very persistent and hazardous. Development of environmental friendly disease control strategies, such as biological control based on the use of protective microorganims, is highly required.
The efficacy of biocontrol agents (when applied as an inoculant) is not always consistent. Fundamental knowledge on the inter actions between the fungus and the biocontrol bacterium is required to understand how the biocontrol bacterium functions at the cellular and molecular level, which forms the basis for the biocontrol effect, and which will contribute to an improved inoculum application.
This study will focus on the biocontrol bacterium Bacillus subtilus strain 49b, which is able to protect tomato roots against the attack of the phytopathogenic fungus Fusarium oxysporum. Bacillus bacteria are very suited for inoculum production since they form heat and drought resistant spores. One of the mechanism through which biocontrol of strain 49b might function is its production of anti fungal metabolites (antibiotics), which after a first analysis seem to be of an unknown class.
The project aims at an integrative approach of biochemical, genetic and microscopic analyses to elucidate the biocontrol mechanism(s) of B. subtilus strain b49. State of the art equipment and methods, including confocal laser scanning microscopy and microarray analysis, will be applied to study the interaction of B. subtilus with the target fungus on the tomato root.
The project will result in the identification of the anti fungal metabolites, elucidate their relevance for biocontrol, identify genes that are relevant for biocontrol ability of B. subtilus. Microscopy studies will visualize the interactions between B. subtilus strain 49b (and mutant derivates) and F. oxysporum at the cellular level.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries agriculture agronomy plant protection
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences microbiology mycology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences physical sciences optics microscopy confocal microscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.