Targeting Myc ubiquitination for cancer therapy

Informations projet

MYC UBIQUITINATION

N° de convention de subvention: 25117

Projet clôturé

Date de début 1 Septembre 2005

Date de fin 31 Août 2007

Financé au titre de

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Coût total Aucune donnée

Contribution de l’UE Aucune donnée

Coordonné par

INSTITUT FüR MOLEKULARBIOLOGIE UND TUMORFORSCHUNG PHILIPPS-UNIVERSITäT MARBURG
Allemagne

Objectif

c-myc is a protooncogene deregulated in a wide range of human cancers. Aberrant Myc expression due to amplifications or translocations is often associated with tumour aggressiveness and poor prognosis.

Importantly, even transient inactivation of Myc is suff icient to inhibit growth of certain tumours making Myc a particularly interesting protein for therapeutic targeting. Involvement of the ubiquitin pathway in regulating Myc function provides a valuable opportunity to modulate activity of this protein.

We propose to identify novel regulators of Myc stability through genome-wide siRNA library screens using fluorescence-based sorting. Based on previous studies, identified molecules will include enzymes that modify Myc directly, such as kinases or acetylases, and may include components of the degradation pathways, such as deubiquitinating enzymes (DUBs).

Many of these enzymes are either known to be suited for pharmacological inhibition (e.g. kinases) or are expected to be so (DUBs are isopeptidases and such enzyme s can be inhibited with small molecules). We expect that this project will define a feasible strategy to target deregulated Myc function in human cancers.

Champ scientifique (EuroSciVoc)

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• sciences médicales et de la santé › médecine clinique › oncologie
• sciences naturelles › sciences biologiques › biochimie › biomolécule › protéines › enzyme

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Programme(s)

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thème(s)

• MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF)

Appel à propositions

FP6-2002-MOBILITY-5
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Régime de financement

EIF -

Coordinateur

INSTITUT FüR MOLEKULARBIOLOGIE UND TUMORFORSCHUNG PHILIPPS-UNIVERSITäT MARBURG

• Contribution de l’UE: Aucune donnée
• Adresse: Allemagne
• Coût total: Aucune donnée