Objetivo In this project we aim to develop a series of metal-containing molecules with the ability to interact with specific DNA sequences. More specifically, we will target what is called quadruplex DNA. It has been recently identified that there are approximately 350,000 sequences in the human genome that can potentially form quadruplex DNA structures. More interestingly, some of these regions have already been identified as potential targets for the development of cancer drugs. Therefore, we will aim to develop metal complexes that can selectively interact with these specific quadruplex DNA structures. The project will involve the design (aided by computational methods), development and characterisation of the new molecules. The DNA binding properties of these molecules will be evaluated using a range of techniques (e.g. FRET, FID, SPR and CD). This will allow us to identify lead molecules (those that interact more strongly and selectively with specific quadruplex DNA structures) so that their biological activity can be evaluated. Ámbito científico natural sciencesbiological sciencesgeneticsDNAnatural sciencescomputer and information sciencescomputational sciencemedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsgenomes Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2009-IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Convocatoria de propuestas FP7-PEOPLE-2009-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Aportación de la UE € 172 240,80 Dirección SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON Reino Unido Ver en el mapa Región London Inner London — West Westminster Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Brooke Alasya (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
