Objective
Molecules containing fluorine (F) atoms have very important roles in medicinal chemistry. F atoms impart certain properties to the biological activity of a drug, such as making it easier to absorb by the body (bioavailability), and greater potency (metabolic stability). On the other hand, being able to produce specific enantiomers (‘mirror images’) of a molecule is also critical, as enantiomers often have very different biological activities. There is a great need to produce optically active molecules containing F atoms, especially for producing drugs and crop protection. One of the most important fluorinated groups is the trifluoromethyl (CF3), which appears in many compounds possessing potent bio- and physicochemical properties, for example efavirenz (antivirotic) and befloxatone (antidepressant). Currently, there are no effective means of achieving enantioselective trifluoromethylation of carbonyl compounds (aldehydes and ketones). In this project, new methods will be developed for the direct asymmetric introduction of CF3 into organic molecules. By designing a brand new class of chiral metal-free phosphorous-containing catalysts to facilitate these reactions, we will provide a way to synthesize optically pure CF3-containing products from carbonyl compounds, in just one step. Successful implementation of the scientific program will enable Dr. Sheshenev to realize his full potential as an independent researcher and reach his ambition to an academic career in the European Union. At the same time, it will also directly benefit the agrochemical and pharmaceutical industries, by enabling them straightforward access to non-racemic fluorinated building blocks of considerable interest, from readily available starting materials. This will raise the profile and maintain the competitiveness of European research in the highly topical areas of asymmetric catalysis and organic synthesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries agriculture agronomy plant protection
- natural sciences chemical sciences organic chemistry aldehydes
- natural sciences chemical sciences organic chemistry ketones
- natural sciences chemical sciences inorganic chemistry halogens
- natural sciences chemical sciences catalysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.