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Mathematical Virology: A classification of virus architecture and the structural transitions important for maturation and infection

Objetivo

This project in Mathematical Biology addresses two important questions concerning the structure and life cycle of viruses: -) The classification of the possible three-dimensional shapes of the capsid proteins compatible with icosahedral symmetry (the most common symmetry of viral capsids) by means of group theory and tiling theory; -) The modeling and prediction of the structural transitions of the viral capsids (protein containers encapsidating the genome) involved in the maturation of the viral particles, using ideas and techniques of the mathematical theory of phase transitions in crystals. The expected results will clarify, on a geometrical basis, the spectrum of structural features that can occur in the viral capsids with icosahedral symmetry (such as the shape and the bonds between the proteins) and elucidate the mechanisms essential for their maturation and infectivity. Such insights have relevant implications for the design of antiviral drugs that inhibit the assembly or the maturation of viral capsids, and the manufacture of self-assembling virus-like containers for drug delivery.

Ámbito científico (EuroSciVoc)

Programa(s)

Tema(s)

Convocatoria de propuestas

FP7-PEOPLE-2009-IEF
Consulte otros proyectos de esta convocatoria

Régimen de financiación

MC-IEF - Intra-European Fellowships (IEF)

Coordinador

UNIVERSITY OF YORK
Aportación de la UE
€ 166 040,80
Dirección
HESLINGTON
YO10 5DD YORK NORTH YORKSHIRE
Reino Unido
Región
Yorkshire and the Humber North Yorkshire York
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
Sin datos