Objective
Development of catalyst-based processes is critical for creating sustainable technology. One such class of reactions, olefin-metathesis mediated by transition metal complexes has recently emerged as a vital tool for organic synthesis. Besides the creation of organic polymers through ring-opening, a new methodology involving tandem synthesis offers a facile route to macrocyclic systems, which now comprise many new pharmaceutical agents. Ruthenium-alkylidene complexes of the Grubbs and Hoydeia variety perform efficient metathesis for a diverse variety of substrates with high functional group tolerance. However, are three main problems encountered with olefin metathesis by these types of complexes, namely, low-yielding asymmetric synthesis, unpredictable cycloisomerization, and inefficient operation under aqueous conditions. The latter has become necessary in order to prepare high molecular weight biological targets. To address these problems, a Ru-based catalyst based on the N,N-chelating ligand, beta-diketiminate, is proposed. Advantages of this ligand include easy and high yielding preparative procedures with flexibility to attach a variety of substituents, including water-soluble functionalities. Furthermore, possibilities exist to create a chiral ligand for promoting asymmetric reactions. Anchoring of the catalyst through attachment of the ligand framework to a solid state support would facilitate high-throughput screening of substrates and assist in the rapid identification of problematic cases. The conditions which promote cycloisomerization over olefin metathesis will also be investigated. Structural data from single crystal X-ray diffraction studies combined with models calculated by the combination of density functional theory and molecular mechanics will help to identity key mechanistic features related to olefin metathesis. These findings, will in turn, be used to adjust and fine-tune the properties of ligand and hence the activity of the catalyst.
Fields of science (EuroSciVoc)
- natural sciences chemical sciences inorganic chemistry organometallic chemistry
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences polymer sciences
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences chemical sciences catalysis
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.