Objective
Transcription in any given cell type is regulated at the level of chromatin, the complex where all nuclear DNA is packaged together with histones. Post-translational modifications at arginine and lysine residues of histones are key regulators of transcription. Furthermore, histone arginine methylation and citrullination appear to be important in the transcriptional control of several developmental processes. In this project, I intend to investigate the role of histone arginine methylation and citrullination in: (1) the maintenance of the pluri/multipotency status of mouse embryonic stem cells and neural stem cells; (2) the specification of neural stem cells, namely into the oligodendrocyte lineage. Increased understanding of the epigenetic regulation of stem cell fate and oligodendrocyte development is of uttermost importance for the development of cell therapies, in particular for demyelinating diseases. This interdisciplinary project will take advantage of my previously acquired expertise in stem cell biology and neural development, and of the host laboratory’s expertise in epigenetics, chromatin and transcription. I will be using leading-edge techniques such as chromatin immunoprecipitation (ChIP) – sequencing and Stable Isotope Labelling by Aminoacids in Cell culture (SILAC) technology, among others. Thus, this project will allow me to get research training in state-of-the-art techniques in the epigenetics field, which will be essential for my plans to become a principal investigator in the area of epigenetic regulation of neural development, with a focus on oligodendrogenesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.