Objective
Genomes are highly dynamic units that often undergo events of reorganization which are formally called developmentally regulated genome rearrangements (DRGRs). DRGRs, like for example chromatin/chromosome elimination or chromatin diminution are widespread throughout eukaryotes (e.g. ciliates, animals, insects, kinetoplastids, foraminifera, entamoebae) and create diversity in genome architecture, often producing significant changes in the fate of the affected cells. The relevance and the consequences of DRGRs have to date received relatively little attention, one reason being that this type of events clash against a commonly, too simplistic, held view that the eukaryotic genome content essentially does not vary among nuclei during an organism’s lifetime. Here, we propose to study the evolution and biological significance of DRGRs by examining one of its best-known and peculiar examples, the massive elimination of so-called internal eliminated sequences (IESs) from the micronuclear DNA of the ciliate Paramecium. Paramecium is a powerful model system that because of its remarkable biological features and molecular tools represents an excellent system to elucidate the evolution of genome architecture. Given the wide phylogenetic distribution of DRGRs, our analysis not only will provide valuable insights about the rates and mechanisms of origin, evolution, and loss of IESs from multiple Paramecium species, possibly reveal the regulatory potential of these non-coding sequens, and improve our understanding of DRGRs in ciliates, but can also lead to the identification of aspects of DRGRs that could be cautiously generalized to other eukaryotic lineages. Notably, a number of features of ciliates that have initially been viewed as odd and unusual have already helped reveal universal molecular processes (e.g. self-splicing RNA, telomere addition).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences zoology entomology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes eukaryotic genomes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
S10 2TN SHEFFIELD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.