Objective
Tumors are by definition both variable and highly adaptive, allowing them to grow beyond their original onset site and invade other organs, and in the process evading physiological intra and extracellular anti-tumor responses, and sometimes chemotherapy. This study proposes that ovarian cancers, and the heterogeneous cells that compose them, can be defined as a cell population(s) with an immature surface and signaling phenotype (with attendant self-replicative capacities) as well as a population(s) of cells with a more 'mature cell' phenotype. The expectation is that these two stages define a parent-daughter cell hierarchy and that this series of maturation events can be modeled akin to normal differentiation – with a set of pools of cells with a defined, stable phenotype linked to each other through transition state intermediates. Here, I apply a single cell systems biology approach to map signaling states at each stage of this proposed cancer-associated differentiation of ovarian cancer using perturbation mapping and high throughput systems biology approaches. The proposal will define the mechanistic underpinnings of ovarian cancer stem cells and the more mature phenotypes, the signaling states of cancer stem cells and daughter cells within patients that are resistant to cancer therapy, and finally a map that delineates the robustness profiles of the cancer-associated differentiation signaling networks and thereby optimal entry points for therapeutic interventions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69117 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.