Objective
During this Fellowship we wish to develop new and synthetically powerful cyclisation cascades using combinations of amine organocatalysts and transition metal catalysts. Carefully chosen combinations of these catalysts should allow ketone functionality to be activated through conversion to a transient enamine intermediate that is then poised to attack the transition metal-activated alkyne or allene functionality. This concept can be extended to new annulation methodology when enone Michael acceptors are employed. In this case carbon acids tethered to alkyne or allene functionality can undergo an initial Michael addition under iminium ion (LUMO lowering) activation using amine organocatalysts and the generated enamine intermediate is then poised to attack the transition metal-activated alkyne or allene group. Furthermore, through use of effective single enantiomer organocatalysts it is possible to render this powerful carboannulation reaction asymmetric. As the majority of pharmaceutical compounds on the market are chiral and sold in single enantiomeric form, the provision of new, synthetically useful asymmetric reactions, reaction cascades and novel catalyst combinations will benefit the synthetic community in Europe by allowing drugs and drug intermediates to be constructed rapidly whilst minimizing waste. It is envisaged that the Fellowship will lead to a detailed understanding of the mechanistic processes and origins of stereocontrol in the developed reactions through employment of physical organic chemistry and computational chemistry techniques to the reactions where relevant. This understanding will further advance the state-of-the-art in field and thus benefit those working in both academia and industry alike. The work will therefore have widespread benefits for the European Community.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry ketones
- natural sciences chemical sciences catalysis
- social sciences economics and business business and management employment
- natural sciences chemical sciences organic chemistry amines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.