Objective
The main objective of the project will be to characterize the molecular cell biology of proliferation in cell-wall deficient (L-form) derivatives of Bacillus. subtilis. L-forms can apparently arise from a wide range of bacteria and are often found in clinical situations. Recent work in the Errington lab has provided a highly tractable model system for studying the L-form state. B. subtilis L-forms proliferate via a remarkable membrane extrusion and resolution mechanism. The aim of the project is to improve our understanding of L-form biology by identifying and characterizing genes required specifically for growth in the L-form state. Two complementary approaches will be used. First, a candidate gene approach, looking at whether genes involved in chromosome segregation or various forms of membrane dynamics are involved. Second, an unbiased genetic screen for such factors. The project will shed light on the basic cell biology of this important and neglected bacterial way of life and provide insights into their remarkable and unexpected mode of proliferation. It may also provide new antibacterial targets for the development of antimicrobial agents acting on persistent bacteria.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences cell biology
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NE1 7RU Newcastle Upon Tyne
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.