Objective
Understanding the function of the gastrointestinal (GI) tract and its relation to abdominal symptoms and digestion is of fundamental importance in clinical medicine. Existing techniques are not able to describe the integrated, regulated mechanism by which foods are digested and drugs are delivered to the bowel. It is for these reasons that the causes of abdominal symptoms often remain unclear and that oral therapies for systemic conditions complicated by GI dysfunction are ineffective. This project will develop and apply MRI technology to assess the flow, mixing and transit of nutrients and oral drugs through the GI tract. Dynamic 1H-MRI will provide a comprehensive assessment of GI function and be combined with novel 19F-MRI that follows the passage of GI contents. Results will be validated and extended by 13C breath testing. The primary objective is to develop multi-nuclear MRI for use in physiologic measurements of GI function (1H-MRI) and delivery of nutrients/drugs (19F-MRI). This includes the optimization of accelerated 3D 1H-MRI for detecting GI function in long bowel segments and 19F-MRI utilizing (nano-)capsules containing a stable fluorocarbon as an oral contrast agent. This technology will be applied in clinical studies of two important diseases to assess whether these developments provide novel insight into the mechanism of disease: (1) Diabetic Mellitus, to assess how gastroparesis leads to abnormal nutrient delivery and impaired glycaemic control. (2) Parkinson’s Disease, to assess how gastric dysfunction affects the delivery and absorption of levodopa and its efficacy for treatment of tremor and rigidity. This project will maintain the leading position of European researchers in MRI assessment of GI function, a technology that is likely to enter clinical practice in the next years. It will increase knowledge about the identification and management of GI complications in DM and PD, chronic diseases that are stated priorities of the FP7 work program.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine
- medical and health sciences medical biotechnology tissue engineering artificial pancreas continuous glucose monitors
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- medical and health sciences basic medicine neurology parkinson
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Zürich
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.