Objective
Currently there is an epidemic of asthma in the western world and the incidence is rising in alarming rates. Experimentation in the asthma field has identified involvement of Th2 cytokines (e.g IL-4 and IL-13), chemokines, mucus hypersecretion, airway obstruction, eosinophilia, enhanced airway hyperreactivity to spasmogens in the asthmatic response and the presence of fibrosis. IL-4 and IL-13, “hallmark” Th2 associated cytokines are markedly elevated in the asthmatic lung and are central regulators of many of the hallmark features of disease and is now viewed as a critical cytokine in disease pathogenesis. Resistin is a hormone that was originally identified in adipose tissue and shown to promote insulin resistance and possibly obesity. However, it is now appreciated that resistin belongs to a newly defined family of resistin-like molecules (Relm) including Relm-alpha, Relm-beta and Relm-gamma that are potent innate immune regulators, and are implicated in Th2-associated immune responses. Indeed, Relm-alpha was originally identified in inflammatory zones associated with an experimental allergic airway disease model and has been called Found in Inflammatory Zones (FIZZ) 1. Recently, I have characterized a pro-inflammatory, regulatory role for Relm-alpha in experimental colitis. Furthermore, I have identified Relm-alpha as one of the highest upregulated IL-13 induced genes in the murine asthmatic lung. Collectively, implicating an important role for Relm-alpha in lung allergic inflammatory responses. The central hypothesis of this grant application is that allergen-induced lung inflammation and fibrosis are regulated by Relm-alpha. To define the role of Relm-alpha in such settings I aim to define the expression pattern, molecular regulation and cellular source for Relm-alpha expression following experimental-asthma and -fibrosis induction. Furthermore, I aim to define the function of Relm-alpha in experimental-asthma and -fibrosis. Finally, I will define the effects o
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69978 Tel Aviv
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.