Objective
The number of people world-wide with end-stage renal disease (ESRD) is increasing every year. Current treatment options consist of dialysis and transplantation, both of which have significant side effects in terms of quality and quantity of life. Therefore there is an urgent need to develop alternative therapies. My recent work has shown that if mouse embryonic stem cells (mESC) are directed to differentiate to mesodermal cells, they show high potential for integrating into developing nephrons in a mouse kidney rudiment ex vivo. Moreover, the ability of mESC –derived mesoderm to generate renal cell types was highly comparable to that of metanephric mesenchyme (MM), which are the cells that give rise to the nephron in the developing kidney. Although these results are encouraging, a key test will be to investigate if the mESC-derived mesoderm cells can generate nephric cell types in a rodent model of kidney disease and if these cells are able to improve renal function. Therefore the aim of this project is to explore the potential for renal replacement therapy from exploitation of the unique properties of mESC. This will be tested by injecting the stem cells into the tail vein of mice with induced kidney injury, following which, the ability of the cells to generate renal cell types and improve renal function will be analysed. The propensity of the stem cells to generate inappropriate cell types or tumours in the animal model will also be tested. A further objective will be to develop an MRI-based tracking system so that the stem cells can be monitored non-invasively following transplantation. The project will form the basis of a long term collaboration between the applicant and the host group at the University of Liverpool.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine transplantation
- medical and health sciences clinical medicine nephrology kidney diseases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
L69 7ZX LIVERPOOL
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.