Objective
miRNAs are key regulators of cell function and pathogen infection. The identification of miRNAs involved inHIV infection promises to offer unique insights into disease mechanisms and to help identify novel targets for therapy. However, the ability to perform an unbiased characterization of miRNA expression has only recently become possible through the use of massive parallel sequencing. This proposal aims to generate the first whole-genome map of miRNA expression during HIV-1 and HIV-2 infection in primary lymphocytes using these novel sequencing techniques. Furthermore, we will identify miRNAs associated with key steps of infection by combining sequencing with the use of drug inhibitors that block viral DNA integration. We expect to identify miRNAs required for the progression of viral infection, with potential for future use in anti-HIV therapy. Pathways associated with differential miRNA expression between HIV-1 and HIV-2 will provide insights into the mildness of HIV-2 infection, providing clues for new strategies against HIV-1.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1749 016 Lisboa
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.