Objective Organic molecules of all shapes and sizes are required for a multitude of applications in numerous settings, such as in the biomedical, pharmaceutical, and agrochemical industries (among others). To meet this demand, organic synthesis is faced with the challenge of converting simple, readily available chemical building blocks into more complex structures in as rapid, efficient, and cost-effective a manner as possible. As such, increasing the efficiency of organic synthesis provides enormous benefits to society, quality of life, and a sustainable future.In this proposal, we outline a program aimed at the design, development, and application of new asymmetric transition metal-catalyzed reactions, where a chiral catalyst will control which particular enantiomer of a chiral product is formed. This feature is absolutely vital, since the action of chiral functional molecules within a chiral environment (such as in biological systems) is critically dependent upon their three-dimensional shape, and hence their enantiomeric composition. Several sub-project areas (each based around transition metal ions for which our group has had prior expertise) are presented, which target compounds from simpler chemical building blocks (copper- and rhodium-catalyzed reactions) to those of higher complexity (nickel-catalyzed domino reactions). During the course of this research, we anticipate that a host of useful discoveries will be made that will positively impact the discipline of organic synthesis for the ultimate benefit of society. Fields of science natural scienceschemical sciencescatalysis Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Call for proposal ERC-2010-StG_20091028 See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Host institution THE UNIVERSITY OF NOTTINGHAM EU contribution € 849 235,25 Address University Park NG7 2RD Nottingham United Kingdom See on map Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Activity type Higher or Secondary Education Establishments Principal investigator Hon Wai Lam (Dr.) Administrative Contact Paul Cartledge (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE UNIVERSITY OF NOTTINGHAM United Kingdom EU contribution € 849 235,25 Address University Park NG7 2RD Nottingham See on map Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Activity type Higher or Secondary Education Establishments Principal investigator Hon Wai Lam (Dr.) Administrative Contact Paul Cartledge (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF EDINBURGH Participation ended United Kingdom EU contribution € 649 656,75 Address OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Angela Noble (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
