Objectif Organic molecules of all shapes and sizes are required for a multitude of applications in numerous settings, such as in the biomedical, pharmaceutical, and agrochemical industries (among others). To meet this demand, organic synthesis is faced with the challenge of converting simple, readily available chemical building blocks into more complex structures in as rapid, efficient, and cost-effective a manner as possible. As such, increasing the efficiency of organic synthesis provides enormous benefits to society, quality of life, and a sustainable future.In this proposal, we outline a program aimed at the design, development, and application of new asymmetric transition metal-catalyzed reactions, where a chiral catalyst will control which particular enantiomer of a chiral product is formed. This feature is absolutely vital, since the action of chiral functional molecules within a chiral environment (such as in biological systems) is critically dependent upon their three-dimensional shape, and hence their enantiomeric composition. Several sub-project areas (each based around transition metal ions for which our group has had prior expertise) are presented, which target compounds from simpler chemical building blocks (copper- and rhodium-catalyzed reactions) to those of higher complexity (nickel-catalyzed domino reactions). During the course of this research, we anticipate that a host of useful discoveries will be made that will positively impact the discipline of organic synthesis for the ultimate benefit of society. Champ scientifique natural scienceschemical sciencescatalysis Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Appel à propositions ERC-2010-StG_20091028 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil THE UNIVERSITY OF NOTTINGHAM Contribution de l’UE € 849 235,25 Adresse University Park NG7 2RD Nottingham Royaume-Uni Voir sur la carte Région East Midlands (England) Derbyshire and Nottinghamshire Nottingham Type d’activité Higher or Secondary Education Establishments Chercheur principal Hon Wai Lam (Dr.) Contact administratif Paul Cartledge (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire THE UNIVERSITY OF NOTTINGHAM Royaume-Uni Contribution de l’UE € 849 235,25 Adresse University Park NG7 2RD Nottingham Voir sur la carte Région East Midlands (England) Derbyshire and Nottinghamshire Nottingham Type d’activité Higher or Secondary Education Establishments Chercheur principal Hon Wai Lam (Dr.) Contact administratif Paul Cartledge (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE UNIVERSITY OF EDINBURGH Participation terminée Royaume-Uni Contribution de l’UE € 649 656,75 Adresse OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Voir sur la carte Région Scotland Eastern Scotland Edinburgh Type d’activité Higher or Secondary Education Establishments Contact administratif Angela Noble (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée