Objective
The main aim of this project is the development of a new technology to produce smart drug delivery
system for chemotherapeutic agents per recognition event. For that affinity-microparticles (10-20 microns
diameter) loaded of paclitaxel (PTX) or Endotastin will be produced.
Microcapsules will be made using a new technology based on the formation of drops from viscous non-
Newtonian liquids sprayed through fan-jet nozzles. This process is based on generation of kinetic energy to a
liquid jet resulting on controlled spray generation. The technique will be modelled in order to ensure the scale-up
the process.
The microparticles, based on alginate polymer, will be functionalised on his surface by affinity ligand, epidermal
growth factor (EGF) which will be able to recognize a specific protein of the tumoral cell, (EGFR) epidermal
growth factor receptor.
Surface plasma resonance will be carried to control the interaction between the microparticle and the protein and
therefore to ensure the efficiency of the microparticles produced. This information will be used to developed a
dynamic model to assess the importance of spatial phenomena and then we will evaluate the accuracy of partial
differential equations (PDEs) in transient when spatial effects are important.
Control release from microcapsules loaded of anticancer agent will be characterized by control release kinetics,
mass transfer, mechanic stability and permeability studies. Mass transfer through the tissue, or therapeutic
leakage from storage cavities and their consequent transport through the organ, are among the several physical
processes, where knowledge of the unsteady transport of a scalar quantity (mass of an active) is of importance
for cell therapy. For that reasons it is necessary to derive an analytical solution for the unsteady mass transport
problem in a porous medium under torsional flow to simulate the diffusion of active materials in body cavities
(Mixed mechanic-electrical model), assuming body cavities as ideally isotropic porous medium.
Finally, characterized microcapsules will be tested in lung tissues with lung cancer. Cell viability (MTT) and
apoptosis after PTX exposure in non small cell lung cancer (NSCLC) will be studied. Morphological distribution
of particles in areas of interest (lung, pleura and lymph nodes) will be examined. The experimental results found
in vitro will compared with experimental animal models developed for tumoral cell death.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology lung cancer
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences polymer sciences
- natural sciences mathematics pure mathematics mathematical analysis differential equations partial differential equations
- medical and health sciences medical biotechnology cells technologies
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-StG_20091028
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
37008 SALAMANCA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.