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A European Infrastructure of Ligand Binding Molecules Against the Human Proteome

Objective

The objective of this proposal is to coordinate the establishment of a European resource infrastructure of binding molecules directed against the entire human proteome. A major objective of the post-genome era is to detect, quantify and characterise all relevant human proteins in tissues and fluids in health and disease. This effort requires a comprehensive, characterised and standardised collection of specific ligand-binding reagents, including antibodies; the most widely used such molecules, as well as novel protein scaffolds and nucleic acid aptamers.

Currently there is no pan-European platform to coordinate systematic development, resource management and quality control for these important reagents. This CA will coordinate 25 European partners and two in the USA, several of which operate infrastructures or large-scale projects in aspects including cDNA collections, protein production, polyclonal and monoclonal antibodies. They provide a critical mass of leading expertise in binder technology, protein expression, binder applications and bioinformatics. Many have tight links to relevant SMEs, as founders or advisors.

The CA will plan the organisation of the resource, by integrating existing infrastructures, reviewing technologies and high throughput production methods, standardising binder-based tools and applications, assembling bioinformatics and establishing a database schema for a central binders repository. The proteome binders' resource is predicted to have huge benefits for basic and applied research, impacting on healthcare, diagnostics, target discovery for drug intervention and therapeutics.

It will thus be of great advantage to the research and biotechnology communities. In general terms, Europe is already well advanced in the technologies required and excellently placed to initiate this large-scale project. The CA will prepare the way for an application for the production phase of the infrastructure under FP7.

Call for proposal

FP6-2004-INFRASTRUCTURES-5
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Coordinator

BABRAHAM BIOSCIENCE TECHNOLOGIES LTD
Address
Babraham Research Campus, Babraham, Cambridge Cb22 3at Babraham Research Campus
Cambridge
United Kingdom

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Participants (29)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3 Rue Michel-ange
Paris

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BEATSON INSTITUTE FOR CANCER RESEARCH
United Kingdom
Address
Switchback Road, Garscube Estate
Glasgow

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DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
Address
Im Neuenheimer Feld 280
Heidelberg

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EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
Heidelberg

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HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
Germany
Address
Inhoffenstraße 7
Braunschweig

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UNIVERSITAET KASSEL
Germany
Address
Monchbergstrasse 19
Kassel

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UNIVERSITAET KONSTANZ
Germany
Address
Universitaetsstrasse 10
Konstanz

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KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
Address
Valhallavaegen 79
Stockholm

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AKADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Address
Albinusdreef 2
PO Box 9600 Leiden

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LOS ALAMOS NATIONAL LABORATORY
United States
Address
Ta-43, Hrl-1
Los Alamos, New Mexico

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LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5c
117 Lund

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MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Hofgartenstrasse 8
Muenchen

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NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN
Germany
Address
Markwiesenstrasse 55
Reutlingen

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MEDICAL FACULTY UNIVERSITY OF RIJEKA
Croatia
Address
Brace Branchetta, 20
Rijeka

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NATIONAL UNIVERSITY OF IRELAND DUBLIN, UNIVERSITY COLLEGE DUBLIN
Ireland
Address
Belfield
Dublin

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RZPD DEUTSCHES RESSOURCENZENTRUM FUER GENOMFORSCHUNG GMBH
Germany
Address
Heubnerweg 6
Berlin

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SOMALOGIC INC
United States
Address
1775 38th Street
Boulder, Co

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TECHNISCHE UNIVERSITAET CAROLO-WILHELMINA ZU BRAUNSCHWEIG
Germany
Address
Pockelsstrasse 14
Braunschweig

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TECHNISCHE UNIVERSITAET MUENCHEN
Germany
Address
Arcisstrasse 21
Muenchen

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UPPSALA UNIVERSITET
Sweden
Address
St Olofsgatan 10b
Uppsala

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VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW
Belgium
Address
Rijvisschestraat 120
Zwijnaarde

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VTT TECHNICAL RESEARCH CENTRE OF FINLAND
Finland
Address
Vuorimiehentie 5
1000 Espoo

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GENOME RESEARCH LIMITED
United Kingdom
Address
215 Euston Road
London

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UNIVERSITAET ZUERICH
Switzerland
Address
Winterthurerstr. 190
Zurich

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THE BABRAHAM INSTITUTE
United Kingdom
Address
Babraham Hall
Cambridge

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IMAGENES GMBH
Germany
Address
Robert-rössle-str.10
Berlin

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ECOLE NATIONALE SUPÉRIEURE D'ELECTRONIQUE, INFORMATIQUE & RADIOCOMUNICATIONS DE BORDEAUX
France
Address
1, Avenue Du Docteur Albert Schweitzer
Talence

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HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT (GMBH)
Germany
Address
Ingolstaedter Landstrasse 1
Neuherberg

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UNIVERSITE VICTOR SEGALEN - BORDEAUX II
France
Address
146, Rue Léo Saignat
Bordeaux

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