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CORDIS

Self-learning modular manufacturing platform for flexible, patient-specific cell production

Objective

Personalized medicine (e.g. regenerative, such as cell therapy or patient-specific tested and composed pharmaceuticals) has huge potential. But to exploit this potential, it is necessary to produce human cells patient-specific in industrial scale. Nowadays, personalized cell production is only executed by means of manual processing on laboratory scale. In Order to make patient-specific production of cells available for a wide range of applications, CytoFab focuses on the development of an intelligent, modular manufacturing platform for flexible, patient-specific cell production which will increase efficiency of personalised cell production in quality and throughput. This objective will be reached by combining several high-sophisticated technologies such as a modular and scalable plug-in concept for the setup of cell production platforms, the application of a cleanroom and sterilisation concept to keep cell cultures cross-contamination free, a micro-fluidic component for customized cell culture medium composition, inline monitoring methodologies to enable the evaluation of cell status within the production process, and a manufacturing execution system which includes a self-learning knowledge-based cell behaviour and advanced cell process control fuctionalities for self-optimization of cell production processes. The latter is needed due to the individual nature of cells which makes it impossible, to process each cell with the same parameters without considerable variations in quality. With this high grade innovations, CytoFab will set a new standard in automated manufacturing technologies for personalized medicine applications.

Call for proposal

FP7-2010-NMP-ICT-FoF
See other projects for this call

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
EU contribution
€ 930 460,00
Address
HANSASTRASSE 27C
80686 Munchen
Germany

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Administrative Contact
Walter Krause (Mr.)
Links
Total cost
No data

Participants (9)