Objective RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design programme. The project aims to identify Small molecule Inhibitor Leads Versus Emerging and neglected RNA viruses (SILVER). It will focus its activities on selected medically important RNA viruses for which the development of drugs is considered essential (Dengue-, entero- and paramyxoviruses), whereas other relatively neglected and/or emerging RNA viruses will be explored to identify the most promising viral protein targets and antiviral compounds. A pipeline strategy has been developed to enable the inclusion in SILVER of viruses at all levels of existing knowledge. Targets for potential drugs include infectious virus, structurally characterised viral enzymes and other proteins. Leads for currently available antiviral drugs have been identified by screening compound libraries in virus-infected cell culture systems and in vitro assays using purified viral enzymes. Selective inhibitors of viral replication have also been (and are being) derived using detailed structural knowledge of viral proteins and structure-based drug design. Hits will be assayed using individual viral protein targets and replicative proteins in complex with viral RNA. The potential protective activity of the most potent inhibitors, that have a favourable (in vitro) ADME-tox profile, will be assessed in relevant infection models in animals. Licenses on promising compounds or compound classes will be presented to the interested pharmaceutical industry. The SILVER consortium will be well placed to play a major role in contributing to the international effort to develop strategies to improve world health. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinemedicinal chemistrymedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronavirusesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.3.3-2 - Drug lead discovery against RNA viruses. FP7-HEALTH-2010-single-stage Call for proposal FP7-HEALTH-2010-single-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSITE D'AIX MARSEILLE Address Boulevard charles livon 58 le pharo 13284 Marseille France See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Higher or Secondary Education Establishments Administrative Contact Céline Damon (Ms.) Links Contact the organisation Opens in new window EU contribution € 2 855 357,30 Participants (23) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAET zu LUEBECK Germany EU contribution € 945 400,00 Address Ratzeburger allee 160 23562 Lubeck See on map Region Schleswig-Holstein Schleswig-Holstein Lübeck, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Margret Schwab (Dr.) Links Contact the organisation Opens in new window Website Opens in new window KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 993 880,00 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Elke Lammertyn (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 744 609,60 Address Albinusdreef 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Marlien Vos (Ms.) Links Contact the organisation Opens in new window Website Opens in new window ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 589 400,00 Address Dr molewaterplein 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Wim Leep (Mr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT PASTEUR France EU contribution € 418 959,60 Address Rue du docteur roux 25-28 75724 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nadia Khelef (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITATSKLINIKUM HEIDELBERG Germany EU contribution € 400 000,00 Address Im neuenheimer feld 672 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Thorsten Brietz (Mr.) Links Contact the organisation Opens in new window Website Opens in new window STICHTING RADBOUD UNIVERSITEIT Participation ended Netherlands EU contribution € 144 982,72 Address Houtlaan 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Wim Van Oijen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window RIBOXX GMBH Participation ended Germany EU contribution € 361 720,00 Address Meissner strasse 191 01445 Radebeul See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jacques Rohayem (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 500 000,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Linda Polik (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 350 000,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Jocelyn Mere (Mr.) Links Contact the organisation Opens in new window Website Opens in new window AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 624 999,56 Address Calle serrano 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Eusebio Jiménez Arroyo (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Global Phasing Limited United Kingdom EU contribution € 400 000,00 Address Newton road 43 CB2 8AL Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gerard Bricogne (Dr.) Links Contact the organisation Opens in new window Website Opens in new window PIKE PHARMA GMBH Participation ended Switzerland EU contribution € 144 673,94 Address Technoparkstrasse 1 CH-8005 Zuerich See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ulrich Kessler (Dr.) Links Contact the organisation Opens in new window UNIVERSITAET INNSBRUCK Austria EU contribution € 375 000,00 Address Innrain 52 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Administrative Contact Kurt Habitzel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAET HAMBURG Germany EU contribution € 375 000,00 Address Mittelweg 177 20148 Hamburg See on map Activity type Higher or Secondary Education Establishments Administrative Contact Jens Bricke (Mr.) Links Contact the organisation Opens in new window Website Opens in new window SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES China EU contribution € 175 000,00 Address Zu chong zhi road zhang jiang high-tech park 555 201203 Shanghai See on map Activity type Research Organisations Administrative Contact Jianmei Shi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY South Korea EU contribution € 0,00 Address Jang dong yusung gu 100 305606 Daejeon See on map Activity type Higher or Secondary Education Establishments Administrative Contact Youngjoo Ko (Dr.) Links Contact the organisation Opens in new window Website Opens in new window National Central University Taiwan EU contribution € 0,00 Address Jhongda road 300 320 Jhongli See on map Activity type Higher or Secondary Education Establishments Administrative Contact Yu-Jin Cheng (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI MILANO Italy EU contribution € 543 000,00 Address Via festa del perdono 7 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Stefania Varotto (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAET LEIPZIG Participation ended Germany EU contribution € 282 674,58 Address Ritterstrasse 26 04109 Leipzig See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Administrative Contact Gerhard Fuchs (Mr.) Links Contact the organisation Opens in new window Website Opens in new window CENTRUM VOOR INNOVATIE EN STIMULATIE VAN MEDICIJNONTWIKKELING LEUVEN VZW Belgium EU contribution € 403 000,00 Address Gaston geenslaan 2 3001 Heverlee See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Research Organisations Administrative Contact Patrick Chaltin (Dr.) Links Contact the organisation Opens in new window UNIVERSITEIT UTRECHT Netherlands EU contribution € 230 017,28 Address Heidelberglaan 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Louise Van Der Kaaden (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window FREIE UNIVERSITAET BERLIN Germany EU contribution € 142 325,42 Address Kaiserswerther strasse 16-18 14195 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Carsten Malmwieck (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
