Objective Assuming an annual birth rate of 10.25 births/1,000 population approximately 25,000 Extremely Low Gestational Age Newborns are born every year in the EU. Conservative figures estimate that approximately half of all these babies will develop low blood pressure and require treatment. However, no uniform criteria exist to define hypotension and the evidence to support our current management strategies is limited. Many of these interventions have been derived from adult literature and have not been validated in the newborn. Dopamine remains the most common inotrope used despite little evidence that it improves outcome. Hypotension is not only associated with mortality of preterm infants but is also associated with brain injury and impaired neurosensory development in ELGAN survivors. Preterm brain injury has far reaching implications for the child, parents, family, health service and society at large. It is therefore essential that we now design and perform the appropriate trials to determine whether the infusion of inotropic agents is associated with improved outcome. We have assembled a consortium with expertise in key areas of neonatal cardiology, neonatology, neurophysiology, basic science and pharmacology with the intention of answering these questions. The objectives of the group are as follows:1. To perform a multinational, randomized controlled trial to evaluate whether a more restricted approach to the diagnosis and management of hypotension compared to a standard approach, with dopamine as a first line inotrope, affects survival without significant brain injury at 36 weeks gestational age in infants born less than 28 weeks gestation and affects survival without neurodevelopmental disability at 2 years corrected age2. To perform pharmacokinetic and pharmcodynamic studies of dopamine3. To develop and adapt a formulation of dopamine suitable for newborns in order to apply for a Paediatric Use Marketing Authorization Fields of science social sciencessociologydemographymortalitymedical and health sciencesclinical medicinecardiologymedical and health sciencesbasic medicinepharmacology and pharmacy Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.4.2-1 - Off-Patent Medicines for Children. FP7-HEALTH-2010-single-stage Call for proposal FP7-HEALTH-2010-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Address Western road T12 YN60 Cork Ireland See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Administrative Contact David O'connell (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (16) Sort alphabetically Sort by EU Contribution Expand all Collapse all KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 483 936,30 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Elke Lammertyn (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERZITA KARLOVA Czechia EU contribution € 208 872,00 Address Ovocny trh 560/5 116 36 Praha 1 See on map Region Česko Praha Hlavní město Praha Activity type Higher or Secondary Education Establishments Administrative Contact Jaromír Chlapec (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CENTRE HOSPITALIER UNIVERSITAIRE SAINTE-JUSTINE Canada EU contribution € 243 375,75 Address Cote sainte catherine 3175 etage c bloc 5 H3T 1C5 Montreal quebec See on map Activity type Research Organisations Administrative Contact Jean Langlais (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland EU contribution € 179 087,00 Address Belfield 4 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Administrative Contact Donal Doolan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE COOMBE LYING-IN HOSPITAL Ireland EU contribution € 438 738,30 Address Dolphins barn cork street Dublin 8 Dublin See on map Activity type Research Organisations Administrative Contact Patrick Donohue (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CLININFO S.A. France EU contribution € 67 575,00 Address Rue de gerland- entree 7 99 69007 Lyon See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Chevarier (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UCL Elizabeth Garrett Anderson Institute for Women’s Health United Kingdom EU contribution € 100 000,00 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data BREPCO BIOPHARMA LTD Ireland EU contribution € 888 000,00 Address Suite one, the avenue, beacon court, sandyford D18 Dublin See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Seamus Oloan (Mr.) Links Contact the organisation Opens in new window Other funding No data GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Participation ended Germany EU contribution € 305 004,43 Address Oskar von miller ring 29 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Fuchs (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 511 500,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nicolas Jeanjean (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE GOVERNORS OF THE UNIVERSITY OF ALBERTA Canada EU contribution € 183 586,50 Address 1-560 enterprise square 10230 jasper avenue research services office T5J 4P6 Edmonton alberta See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lorraine Deydey (Ms.) Links Contact the organisation Opens in new window Other funding No data ROYAL COLLEGE OF SURGEONS IN IRELAND Ireland EU contribution € 162 635,40 Address St stephen's green 123 2 Dublin See on map Region Ireland Northern and Western Border Activity type Higher or Secondary Education Establishments Administrative Contact Barry Mcgowan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAIR ZIEKENHUIS ANTWERPEN Belgium EU contribution € 60 000,00 Address Drie eikenstraat 655 2650 Edegem See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Research Organisations Administrative Contact Daisy Van Mieghem (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FAKULTNI NEMOCNICE OSTRAVA Czechia EU contribution € 50 000,00 Address 17 listopadu 1790 708 52 Ostrava poruba See on map Region Česko Moravskoslezsko Moravskoslezský kraj Activity type Research Organisations Administrative Contact David Feltl (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KRAJSKA NEMOCNICE T. BATI AS Czechia EU contribution € 50 000,00 Address Havlickovo nabrezi 600 76275 Zlin See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ladislava Martincová (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ARTTIC France EU contribution € 126 705,57 Address 39 rue des mathurins 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martin Dietz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
