Objective
The worst of evils - pain is one of the main reasons for seeking medical help. Chronic pain affects almost one fifth of the population of Europe and leads to exorbitant medical expenses as well as extreme suffering. Despite extensive efforts, effective pain treatment has remained elusive. Inadequate understanding of the mechanisms of pain prevents the development of effective therapies. In order to better understand pain mechanisms, a novel integrative approach is needed. This approach should: to investigate the fundamental site of signal detection; the nociceptive terminals and to establish an understanding of the progression from peripheral nociception to central pain perception. Our project aims to integrate analysis at different levels of pain perception in normal and pathological conditions in order to elucidate mechanisms underlying chronic pain. Our approach propose to study pain related mechanisms along somatotopically define neuroaxis of vibrissae-barrel system. Using this unique system where peripheral receptor directly corresponds to its central analyzer, we will first characterize noxious signal detection by single channels in individual nociceptive terminal. We will follow propagation of nociceptive signal and monitor activity-dependent changes in corresponding circuits at trigeminal nuclei, thalamus and cortex. We will study modulation in of synaptic connectivity in the spino-thalamo-cortical pathway in models of chronic pain. This multi-disciplinary project will incorporate ground-breaking imaging techniques and state-of-the-art electrophysiological, histological and behavioural experiments to study pain-related mechanisms at the molecular and cellular levels as well as at the level of neuronal networks and behaviour.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-StG_20091118
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
91904 JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.