Objective Chronic hepatitis B virus (HBV) infection affects 350 million people worldwide and 25-30% of these individuals will die as a result of their infection mainly as a results of hepatocellular carcinoma HCC. Liver cirrhosis, high viral load and dietary exposure to aflatoxin are recognised as risk factors for hepatocellular carcinoma amongst HBV carriers. However, these variables do not account for all cases of HCC and decompensated cirrhosis is rarely ever seen in West Africa suggesting that advanced liver fibrosis may not be an important risk factor in this population. A large case control study on HCC will be used to evaluate the importance of liver fibrosis and other established risk factors in West Africa and to explore other potential oncogenic determinants. The case-control study will generate serum, urine and DNA samples for proteomic, metabonomic and genomic analysis to identify biomarkers and aetiological agents for HCC.Effective treatment for HBV infection is now available in the developed world but treatment programmes have not been developed for resource poor settings even though some of the effective medication is now available at low cost for HIV management. A trial of HBV treatment in a group of carefully selected high risk patients will be conducted to demonstrate that the incidence of HCC can be reduced in this population as has been observed in Asian patients. The treatment trial will also be used to evaluate the efficacy of screening by ultrasound for early tumours which can be treated with percutaneous alcohol injection.This comprehensive programme therefore aims to reveal novel aetiological factors for HCC, identify and evaluate biomarkers and demonstrate the efficacy of selective antiviral therapy to prevent HCC Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health scienceshealth sciencesinfectious diseasesDNA viruseshepatitis Bmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicineoncologymedical and health sciencesclinical medicinehepatology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.1-4 - Infectious agents and cancer in Africa Call for proposal FP7-AFRICA-2010 See other projects for this call Funding Scheme CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA) Coordinator IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Address South kensington campus exhibition road SW7 2AZ London United Kingdom See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 642 000,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 1 105 300,00 Address 20 park crescent W1B 1AL London See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Tumani Corrah (Prof.) Links Contact the organisation Opens in new window Website Opens in new window CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER France EU contribution € 236 000,00 Address 25 avenue tony garnier 69007 Lyon 7eme See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Research Organisations Administrative Contact Olaf Kelm (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 158 000,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Administrative Contact Hiba Vergnaud (Ms.) Links Contact the organisation Opens in new window Website Opens in new window JOS UNIVERSITY TEACHING HOSPITAL Nigeria EU contribution € 189 500,00 Address Murtala mohammed way plateau state 930001 Jos See on map Activity type Higher or Secondary Education Establishments Administrative Contact Edith Okeke (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE CHEIKH ANTA DIOP DE DAKAR Senegal EU contribution € 324 000,00 Address Avenue martin luther king - Dakar fann See on map Activity type Higher or Secondary Education Establishments Administrative Contact Souleymane Mboup (Prof.) Links Contact the organisation Opens in new window Ministry of Health and Social Welfare The Gambia EU contribution € 137 200,00 Address The quadrangle, banjul Banjul See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Makie Taal (Dr.) Links Contact the organisation Opens in new window XEPTAGEN SPA Italy EU contribution € 208 000,00 Address Via delle industrie 9 30175 Venezia See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Giorgio Fassina (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
