Objective In the development of products for use by humans it is vital to identify compounds with toxic properties at an early stage of their development, to avoid spending time and resource on unsuitable and potentially unsafe candidate products. Human pluripotent stem cell lines offer a unique opportunity to develop a wide variety of human cell-based test systems because they may be expanded indefinitely and triggered to differentiate into any cell type. SCR&Tox aims at making use of these two attributes to provide in vitro assays for predicting toxicity of pharmaceutical compounds and cosmetic ingredients. The consortium has been designed to address all issues related with biological and technological resources to meet that goal. In order to demonstrate the value of pluripotent stem cells for toxicology, the consortium will focus on four complementary aspects: Relevance –i.e. establishing and maintaining discrete cell phenotypes over long-term cultures; providing large versatility to adapt to assays of specific pathways. Efficiency –for i) automated cell production and differentiation, ii) cell engineering for differentiation and selection iii) multi-parametric toxicology using functional genomic, proteomic and bioelectronics. Extension –i.e. i) scalability through production of cells and technologies for industrial-scale assays, and ii) diversity of phenotypes (5 different tissues), and of genotypes (over 30 different donors). Normalization –validation and demonstration of reproducibility and robustness of cell-based assays on industrial-scale platforms, to allow for secondary development in the pharmaceutical and cosmetic industry. SCR&Tox will be intricately associated to other consortia of the “Alternative Testing” call, sharing biological, technological and methodological resources. Proof of concept of the proposed pluripotent stem cell-based assays for toxicology will be provided on the basis of toxicity pathways and test compounds identified by other consortia. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicinetoxicology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.4.2-9-1 - Optimisation of current methodologies and development of novel methods to achieve functional differentiation of human-based target cells in vitro. FP7-HEALTH-2010-Alternative-Testing-Strategies Call for proposal FP7-HEALTH-2010-Alternative-Testing See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Address Rue de tolbiac 101 75654 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Laurie Louis-Joseph (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 101 929,33 Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITATSKLINIKUM BONN Germany EU contribution € 399 218,00 Address Venusberg-campus 1 53127 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Becker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Takara Bio Europe AB Sweden EU contribution € 612 269,00 Address Arvid wallgrens backe 413 46 Göteborg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Karina Lövstedt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CELLECTIS SA Participation ended France EU contribution € 171 030,56 Address Rue jean antoine de baif 12 75013 Paris See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patricia Sosa Navarro (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CXR Biosciences Limited United Kingdom EU contribution € 237 205,77 Address James lindsay place DD1 5JJ Dundee See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gavin Hands (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAET LEIPZIG Germany EU contribution € 293 322,88 Address Ritterstrasse 26 04109 Leipzig See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Administrative Contact Gerhard Fuchs (Mr.) Links Contact the organisation Opens in new window Website Opens in new window CIT SAS France EU contribution € 236 858,94 Address Miserey 27005 Evreux See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Spies (Mr.) Links Contact the organisation Opens in new window Website Opens in new window LABCORP EARLY DEVELOPMENT LABORATORIES LIMITED United Kingdom EU contribution € 236 576,35 Address Otley road HG3 IPY Harrogate See on map Region Yorkshire and the Humber North Yorkshire North Yorkshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Robert Greenhalf (Mr.) Links Contact the organisation Opens in new window Website Opens in new window JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION Belgium EU contribution € 313 426,65 Address Rue de la loi 200 1049 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Research Organisations Administrative Contact Iain Formosa (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ASTRAZENECA AB Sweden EU contribution € 226 936,70 Address Vastra maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Per Hall (Mr.) Links Contact the organisation Opens in new window Website Opens in new window KAROLINSKA INSTITUTET Sweden EU contribution € 267 996,96 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Eva Gipperth (Ms.) Links Contact the organisation Opens in new window Website Opens in new window AVANTEA srl Italy EU contribution € 155 570,00 Address Via cabrini 12 26100 Cremona See on map Region Nord-Ovest Lombardia Cremona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anna D Apolito (Ms.) Links Contact the organisation Opens in new window Website Opens in new window HEALTH PROTECTION AGENCY HPA Participation ended United Kingdom EU contribution € 119 454,18 Address Buckingham palace road 151 SW1W 9SZ London See on map Activity type Research Organisations Administrative Contact Amanda King (Ms.) Links Contact the organisation Opens in new window Website Opens in new window INSERM TRANSFERT SA France EU contribution € 160 800,00 Address 10 rue d'oradour-sur-glane - parisante campus 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Louis Jammayrac (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Department of Health United Kingdom EU contribution € 167 404,68 Address Quarry house, quarry hill LS2 7UE Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Research Organisations Administrative Contact Amanda King (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window
