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Nanoscale Functionalities for Targeted Drug Delivery of Biopharmaceutics

Objective

The Integrated Project NanoBioPharmaceutics aims at the development of innovative multidisciplinary approaches for the design, synthesis and evaluation of functionalised nano-carriers and nano-particle-based micro-carriers for the treatment of various diseases based on targeted, controlled delivery of therapeutic peptides and proteins (biopharmaceutics).

More specifically, the present IP aims at the following scientific and technological objectives:
1. Design, synthesis and functionalization of novel nano-carriers and nano-particle-based micro-carriers for targeted delivery of P/P drugs via oral, pulmonary and Blood Brain Barrier (BBB) crossing administration routes.
2. Toxicological screening of the nano-carriers and investigation of the release profile of P/P drug under various environmental conditions and the assessment of the biocompatibility and biodegradability of the new formulations.
3. Novel pulmonary P/P carriers with improved delivery features to overcome the administration difficulties and increase efficiency of protein delivery to the deep lung.
4. Oral nano-particulate P/P carrier systems capable of adhering to the gastrointestinal mucosa and also displaying protective and permeation enhancing properties.
5. Establishment of an in vitro model for the assessment of nano-carriers permeability through the Blood Brain Barrier (BBB).

The present IP integrates the scientific activities and complementary skills of researchers coming from 13 EU countries and the state of Israel, in an attempt to ensure breakthrough advances in novel biopharmaceutics delivery systems. The Consortium consists of 12 University departments, 6 research institutes, 6 SMEs and 3 large industries. An efficient management scheme has been established to ensure the fulfilment of the IP's scientific, technological and exploitation objectives.

Call for proposal

FP6-2004-NMP-NI-4
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Coordinator

DECHEMA GESELLSCHAFT FUER CHEMISCHE TECHNIK UND BIOTECHNOLOGIE E.V.
Address
Theodor-heuss-allee 25
Frankfurt Am Main
Germany

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Participants (26)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Address
Ecublens
Lausanne

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UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG UNIVERSITAT MAINZ
Germany
Address
Langenbeckstr. 1
Mainz

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MEDIZINISCHE UNIVERSITAET GRAZ
Austria
Address
Universitaetsplatz 3
Graz

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TEL AVIV UNIVERSITY
Israel
Address
Ramat Aviv
Tel Aviv

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UNIVERSITE DE LIEGE
Belgium
Address
Place Du Xx Aout 7
Liege

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UNIVERSITAET INNSBRUCK
Austria
Address
Innrain 52
Innsbruck

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INSTITUT QUIMIC DE SARRIA
Spain
Address
Calle Via Augusta 390
Barcelona

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UNIVERSITEIT TWENTE
Netherlands
Address
Drienerlolaan 5
217 Enschede

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CHALMERS TEKNISKA HOEGSKOLA AKTIEBOLAG
Sweden
Address

Goeteborg

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DEUTSCHES WOLLFORSCHUNGSINSTITUT AN DER RWTH AACHEN E.V.
Germany
Address
Veltmanplatz 8
Aachen

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UNIVERSITEIT MAASTRICHT
Netherlands
Address
Minderbroedersberg 4-6
616 Maastricht

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CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH POLSKIEJ AKADEMII NAUK
Poland
Address
Ul. Sienkiewicza 112
Lodz

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JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH
Austria
Address
Steyrergasse 17
Graz

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KEMIJSKI INSTITUT LJUBLJANA SLOVENIJA
Slovenia
Address
Hajdrihova 19
660 Ljubljana

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NATIONAL CENTRE FOR SCIENTIFIC RESEARCH "DEMOKRITOS"
Greece
Address
Patriarchou Gregoriou Str.
60228 Aghia Paraskevi

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LEK FARMACEVTSKA DRUZBA DD - LEK PHARMACEUTICALS
Slovenia
Address
Verovskova 57
Ljubljana

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MAGNAMEDICS GMBH
Germany
Address
Martelenberger Weg 8
Aachen

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REGULON SA
Greece
Address
Grigoriou Afxentiou 7, Alimos
Athens

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THIOMATRIX FORSCHUNGS- UND BERATUNGS GMBH
Austria
Address
Unterer Platz 22
St. Veit An Der Glan

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LIPOXEN TECHNOLOGIES LIMITED
United Kingdom
Address
Suite 303, Hamilton House, Mabledon Place
London

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NOVO NORDISK A/S
Denmark
Address
Novo Alle, 6a 1.027
Bagsvaerd

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APLAGEN GMBH
Germany
Address
Arnold-sommerfeld-ring 2
Baesweiler

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GLAXOSMITHKLINE BIOLOGICALS S.A.
Belgium
Address
Rue De L'institut 89
Rixensart

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Centre for Research and Technology Hellas
Greece
Address
6th Km Charilaou-thermi Road
361 Thermi-thessaloniki

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SUSTECH GMBH AND CO. KG
Germany
Address
Petersenstrasse 20
Darmstadt

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UNIVERSITA DEGLI STUDI DI TRIESTE
Italy
Address
Piazzale Europa 1
Trieste

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