Objective
The gut and the liver are the key organs in nutrient absorption and metabolism. The gut adapts to the composition of the diet by direct substrate effects in addition to neural and endocrine mechanisms. These adaptations include the intestinal mucosa and the gut microbiota. Depending on the diet, the profile of nutrients, metabolites, gut peptides and other mediators released from the gut can be modified.
The liver is the first organ which comes into contact with the molecules arising from gut digestion. Nutrients and metabolites delivered from the intestine are sensed in the liver and trigger an adaptation of liver function to improve their hepatic processing. These processes together with neural and endocrine mechanisms regulate liver function and exert a direct or indirect feedback control of gut function.
This project aims to evaluate the consequences of increasing protein in a context of either a high carbohydrate or a high fat diet on the adaptation of the gut-liver axis in rodents. A high carbohydrate diet induces hepatic steatosis through the stimulation of hepatic lipogenesis. In contrast, a high fat diet is believed to induce liver metabolic dysfunction and steatosis through dietary fat accumulation but also by inducing gut bacterial overgrowth and endotoxemia leading to a pro-inflammatory state in the gut-liver axis.
In order to evaluate the effect of protein in both situations, animals are adapted for several weeks to 4 diets including a control high carbohydrate diet, a high protein-low fat diet, a high fat diet and a high fat-high protein diet. The analyses include gene expression and metabolic phenotyping in the gut mucosa and liver, characterisation of the microbiota, gut, liver and peripheral inflammatory state, hepatic lipogenesis and steatosis, glucose homeostasis, protein turnover in tissues, energy expenditure, substrate oxidation, body composition and food intake behaviour.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences nutrition
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6708 PB Wageningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.