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Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons

Objective

In the present proposal, we plan to examine the dendrites, axons, and presynaptic terminals of fast-spiking, parvalbumin-expressing GABAergic interneurons using subcellular patch-clamp methods pioneered by the PI, imaging techniques, and computational approaches.
The goal is to obtain a quantitative nanophysiological picture of signaling in this key type of interneuron. By incorporating realistic BC models into dentate gyrus network models, we will be able to test the contribution of this important type of GABAergic interneuron to complex functions of the dentate gyrus, such as pattern separation, temporal deconvolution, and conversion from grid to place codes. The results may lay the basis for the development of new therapeutic strategies for treatment of diseases of the nervous system, targeting interneurons at subcellularly defined locations.

Field of science

  • /natural sciences/biological sciences/neurobiology

Call for proposal

ERC-2010-AdG_20100317
See other projects for this call

Funding Scheme

ERC-AG - ERC Advanced Grant

Host institution

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Address
Am Campus 1
3400 Klosterneuburg
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 500 000
Principal investigator
Peter Jonas (Prof.)
Administrative Contact
Carla Mazuheli-Chibidziura (Ms.)

Beneficiaries (1)

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Austria
EU contribution
€ 2 500 000
Address
Am Campus 1
3400 Klosterneuburg
Activity type
Higher or Secondary Education Establishments
Principal investigator
Peter Jonas (Prof.)
Administrative Contact
Carla Mazuheli-Chibidziura (Ms.)