Objective In the present proposal, we plan to examine the dendrites, axons, and presynaptic terminals of fast-spiking, parvalbumin-expressing GABAergic interneurons using subcellular patch-clamp methods pioneered by the PI, imaging techniques, and computational approaches.The goal is to obtain a quantitative nanophysiological picture of signaling in this key type of interneuron. By incorporating realistic BC models into dentate gyrus network models, we will be able to test the contribution of this important type of GABAergic interneuron to complex functions of the dentate gyrus, such as pattern separation, temporal deconvolution, and conversion from grid to place codes. The results may lay the basis for the development of new therapeutic strategies for treatment of diseases of the nervous system, targeting interneurons at subcellularly defined locations. Fields of science natural sciencesbiological sciencesneurobiology Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-LS5 - ERC Advanced Grant - Neurosciences and neural disorders Call for proposal ERC-2010-AdG_20100317 See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Coordinator INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Address Am campus 1 3400 Klosterneuburg Austria See on map Region Ostösterreich Niederösterreich Wiener Umland/Nordteil Activity type Higher or Secondary Education Establishments Administrative Contact Carla Mazuheli-Chibidziura (Ms.) Principal investigator Peter Jonas (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Austria EU contribution € 2 500 000,00 Address Am campus 1 3400 Klosterneuburg See on map Region Ostösterreich Niederösterreich Wiener Umland/Nordteil Activity type Higher or Secondary Education Establishments Administrative Contact Carla Mazuheli-Chibidziura (Ms.) Principal investigator Peter Jonas (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
