Objective The ChemBioFight project aims towards the exploration of natural resources to the discovery of bioactive therapeutic molecules against leishmania and Chagas disease. This will be accomplished through the establishment of an extended scientific network between European and South American research entities. Already assembled, highly diverse chemical libraries will be employed for the determination of active natural scaffolds leading to the focused collection of biomaterial (plants, marine organisms, fungi, endophytes) from local diversity hot-spots. Automated, high throughput and advanced techniques will be incorporated for the extraction process as well as the isolation and identification of natural products. Sophisticated approaches as metabolomics and chemical profiling will contribute to the discovery of novel active compounds and will be used to conduct dereplication procedures. Semi-synthetic derivatives of lead compounds will be also produced aiming to the optimization of favorable biological properties via medicinal chemistry aspects. In every step of the proposed work flow, the obtained samples (extracts, isolated compounds, synthetic derivatives) will be evaluated in vitro and/or in vivo for their antileishmanial and antitrypanosomal activity. Within the aforementioned context, an extensive net of secondements, both with educational and experimental attributes, will be established. Core scientific knowledge is expected to be produced and exchanged, with the prospect of creating partnerships with future scientific potential. All partners will participate in the dissemination procedure through teaching activities, workshops and international conferences, leading overall to mutual transfer of know-how. Finally, all procedures will be effectively monitored from a management team ensuring effectiveness and prompt objective achievement. Fields of science medical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencesmicrobiologymycologynatural sciencesbiological sciencesecologyecosystems Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2010-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Call for proposal FP7-PEOPLE-2010-IRSES See other projects for this call Funding Scheme MC-IRSES - International research staff exchange scheme (IRSES) Coordinator ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Address 6 christou lada str 10561 Athina Greece See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Administrative Contact Efi Kafentzi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE DE GENEVE Switzerland EU contribution € 88 200,00 Address Rue du general dufour 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Jean-Luc Wolfender (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Université Paris Descartes France EU contribution € 115 500,00 Address Rue de l'ecole de médecine 75270 cedex 06 Paris See on map Activity type Higher or Secondary Education Establishments Administrative Contact Stephan Sirven Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITEIT LEIDEN Netherlands EU contribution € 39 900,00 Address Rapenburg 70 2311 EZ Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Ton Brouwer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data HELLENIC PASTEUR INSTITUTE Greece EU contribution € 48 300,00 Address Vassilissis sofias avenue 127 11521 Athens See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Evgenia Konstantaki (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
