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Combining epidemiology and radiobiology to assess cancer risks
in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below

Objective

Recent epidemiological studies suggest that cancer risk after exposures with doses comparable to the dose limits for occupationally exposed workers may be larger than assumed by ICRP in the derivation of these limits. The value of cancer risk from such exposures and its dependence on tissue, radiation type and individual factors is largely unknown. The innovative approach proposed here combines epidemiology and radiobiology in order to quantify cancer risks after low-dose or low-dose-rate exposures to ionizing radiation. Key factors of radiation induced carcinogenesis such as genomic instability will be measured in cancer tissues and blood samples from members of the following radio-epidemiological cohorts: French Haemangioma Cohort, Mayak Worker Cohort and thyroid cancer cases after the Chernobyl accident. Inter-cellular communication after exposure to low-dose radiation exposure and its influence on apoptosis, cell proliferation, differentiation and genomic instability will be explored with 2D cell cultures and 3D tissue models. This includes research on stem cells, which will be isolated from healthy human breast tissue. The results of the radiobiological studies will be integrated in the development of models of carcinogenesis for evaluation of major epidemiological cohorts: Atomic Bomb Survivors, French-Swedish-Italian Thyroid Cancer Cohort, Mayak Worker Cohort, Swedish Haemangioma Cohort, UkrAm Cohort on thyroid cancer after the Chernobyl accident, and UK National Registry for Radiation Workers. Cancer risk will be determined for the breast, lung, thyroid and the digestive tract after low-dose-rate exposure to low-LET radiation (external gamma radiation and internal radiation from 131I) and to high-LET radiation (alpha-particles from incorporated plutonium). Lifetime cancer risks including individual risk factors will be calculated to establish a new basis for deriving dose limits and estimating cancer risks including those from medical diagnostic exposures.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer
  • /medical and health sciences/health sciences/epidemiology

Call for proposal

FP7-Fission-2010
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Germany
Activity type
Research Organisations
EU contribution
€ 1 408 000
Administrative Contact
Jurgen Ertel (Dr.)

Participants (19)

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 448 000
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Jacqueline Hiridjee (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 333 002
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Polik (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 323 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Teddy Petris (Mr.)
SATEILYTURVAKESKUS
Finland
EU contribution
€ 302 856
Address
Laippatie 4
00880 Helsinki
Activity type
Research Organisations
Administrative Contact
Liisa Sirkka (Ms.)
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 338 000
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Brunelli (Dr.)
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 303 000
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Petterson (Ms.)
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 302 569,20
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kevin Prise (Prof.)
UNIVERSITAET ROSTOCK
Germany
EU contribution
€ 303 000
Address
Universitatsplatz 1
18055 Rostock
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Guido Hildebrandt (Prof.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 313 000
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Falko Fend (Prof.)
FEDERAL STATE UNITARY ENTERPRISE SOUTHERN URALS BIOPHYSICS INSTITUTE OF FEDERAL MEDICOBIOLOGICAL AGENCY
Russia
EU contribution
€ 308 000
Address
Ozyorskoe Shosse 19
456780 Ozyorsk
Activity type
Research Organisations
Administrative Contact
Tamara Azizova (Dr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 193 000
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Erik Holmberg (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 152 870
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Von Witting (Ms.)
Public Health England an Executive Agency of the Dept of Health

Participation ended

United Kingdom
EU contribution
€ 8 852
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Beril Short (Ms.)
V.P. KOMISARENKO INSTITUTE OF ENDOCRINOLOGY AND METABOLISM
Ukraine
EU contribution
€ 73 000
Address
Vyshgorodska Str 69
04114 Kiyv
Activity type
Research Organisations
Administrative Contact
Tetiana Bogdanova (Prof.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 273 776
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tania Palalic (Ms.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michel Telkamp (Mr.)
SEMIOSHKINA NATALIA
Germany
EU contribution
€ 76 800
Address
Liebigstrasse 3
80538 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Natalia Semioshkina (Dr.)
STICHTING VU
Netherlands
EU contribution
€ 223 200
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michel Telkamp
Department of Health
United Kingdom
EU contribution
€ 134 148
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Administrative Contact
Svetlana Carr (Mrs.)