Objective
Nerve repair depends critically on injury-induced Schwann cell dedifferentiation, an adaptive injury response that generates the denervated Schwann cell, a cell that enables peripheral nerves, unlike CNS tissue, to regenerate after injury. The transcriptional programmes that control the generation of the denervated repair cells are therefore an important issue in nerve biology.
The host laboratory has recently defined the concept of negative regulation of myelination, implicated two transcriptional regulators, c-Jun and Notch, in the control of dedifferentiation and the formation of the denervated cell, and shown that Schwann cell c-Jun has an essential role in controlling nerve regeneration.
In peripheral nerves, the Signal Transducer and Activator of Transcription 3 (STAT3) is rapidly activated at the injury site following nerve transection, but the function of this factor in nerve injury has not been investigated. Perhaps the best known function of STAT3 is the positive regulation of cellular survival, a function that in many cell types is mediated by its ability to up-regulate the gene expression of Bcl-xL and Bcl-2, anti-apoptotic factors. Mechanisms that ensure the sufficient Schwann cell survival in injured nerves are critical for nerve repair.
Thus, the present project will explore additional control systems in injured nerves and in particular whether STAT3 signalling in Schwann cells is an important mediator of the adaptive injury response of these cells in damaged nerves. Our key aims are to test whether STAT3 is required for the survival of denervated Schwann cells, the formation of the Schwann cell columns (bands of Bungner) that serve as substrates for regenerating axons and the remyelination of regenerated axons.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering control systems
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 6BT LONDON
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.