Objective
An important aspect of chronic neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Huntington’s or prion disease, is the generation of an innate inflammatory reaction within the central nervous system. Microglial cells play a leading role in the development and maintenance of this inflammatory reaction, showing enhanced proliferation and morphological activation. Moreover, during neurodegeneration and inflammation, the mechanisms that control neural stem cell biology are altered and may also affect disease progression, causing impaired neural stem cell renewal, migration and differentiation. Since these proliferative responses are both involved in neurodegeneration they may share common or perhaps antagonistic regulatory pathways.
In this project, using a tractable laboratory model of neurodegeneration (murine prion disease), we will study the time-course and molecular regulation of microglial and neural stem cell proliferative responses. Moreover, we will analyze the role of the inflammatory milieu in the regulation of the proliferative responses, in order to throw light on the progression of chronic neurodegeneration. These objectives will be addressed using a multidisciplinary technical approach, combining the use of transgenic animal models with cell culture systems, analyzed by cellular and molecular biology techniques. Furthermore, we will cross-validate our studies with the analysis of the microglial and neural stem cell proliferative responses in post-mortem brain samples from Alzheimer’s disease patients. This powerful combined approach would permit us to obtain results that will contribute to the understanding of mechanisms that drive progression of chronic neurodegeneration.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine neurology parkinson
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SO17 1BJ SOUTHAMPTON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.