Objective Breast cancer is a heterogeneous disease, which includes many different types of cancers with diverse histopathologies, genetic and genomic variations, and clinical outcomes. Pathological states of the breast, such as pre-neoplastic lesions and carcinomas, retain aspects of cellular composition observed in the normal breast. It is not clear if the heterogeneity of breast cancer reflects the same hierarchical pattern of the normal tissue. In particular, the question remains as to whether specific molecular pathways establish the subtype of breast cancer or whether different cell types within the breast hierarchy become transformed and give rise to each tumour subtype. Currently, one of the major limitations in the field consists of a lack of experimental model systems that correctly recapitulate the pathogenesis of human breast tumours.The main aim of this project is to study the cellular origin of breast cancer. In order to use a model which more closely recapitulates the human pathogenesis of breast cancer in a relatively short time frame as compared to traditional transgenic mice models, we will develop a novel system which will be used to address several important questions. The model will provide a powerful tool to dissect the contribution of oncogenes and targeted cells to the development of specific types of cancer. The system generated will also provide a relatively rapid breast cancer model which will allow us to study the contribution of selected factors, already described in the host laboratory to be important in mammary gland development and possibly tumourigenesis. Fields of science medical and health sciencesclinical medicineoncologybreast cancer Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Call for proposal FP7-PEOPLE-2010-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Address Trinity lane the old schools CB2 1TN Cambridge United Kingdom See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Christine Jannette Watson (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data