Objective Molecular recognition at bilayer membranes is key to many vital processes in biology, yet notoriously difficult to study. Aim of this project is to introduce a new technique to this field: dynamic combinatorial chemistry. We propose to adapt reversible thioester chemistry to this end and use it for two different purposes:(i) Discovering new synthetic receptors that are optimized for operating at the bilayer interface. This should lead to new fundamental insights into what differentiates molecular recognition at the lipid bilayer interface from the corresponding process in solution.(ii) Unraveling the mode of action of gramicidin antibiotics through covalent capture of the self-assembled superstructures formed upon incorporation of this compound in the bilayer membrane. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Call for proposal FP7-PEOPLE-2010-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator RIJKSUNIVERSITEIT GRONINGEN Address Broerstraat 5 9712CP Groningen Netherlands See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Administrative Contact H.D Veldhuis (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
