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Content archived on 2024-06-18

Clonal analysis in pancreatic development, differentiation and carcinogenesis

Objective

The knowledge about pancreas development and the establishment of pancreatic cell lineages has exploded in recent years. These studies are important in developing strategies for regenerative medicine. On the other hand, pancreatic ductal adenocarcinoma (PDAC) is the tumor with the worst prognosis in humans: its incidence rate is equivalent to its mortality rate, with a median survival of less than 6 months. In this project, we will use retrospective clonal analysis to analyze the clonal structure of the mouse pancreas. Unlike other lineage tracing studies, the technique proposed allows the analysis of individual, low-frequency, clones. By doing this we pretend to dealwith questions such as clonality, clonal size and clonal variation in the embryonic pancreas. Moreover, we aim at developing strategies to analyze quantitatively the adult pancreas, not only in normal conditions but also in situations where the pancreas structure is disrupted by disease. We will thus use models of experimental pancreatitis. In the final step of this project, we pretend to set up the basis to use our clonal approach with murine PDAC murine models, using both genetic mouse models and carcinogen treatment. The work will impy two host groups with distinct and complementary expertise: developmentl biology and pancreas cancer biology. This kind of approach will become important in cancer research in the future in order to understand clonal evolution. The proposed project builds on the experience of the candidate and will allow him to acquire new expertise in cancer biology in order to establish his scientific career in the future.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2010-IEF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
EU contribution
€ 230 980,00
Address
C MELCHOR FERNANDEZ ALMAGRO 3
28029 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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