Objective
Enantioselective Isocyanoacetate Addition Reactions under Cooperative Base and Lewis Acid Catalysis. Enantiomerically pure substances with the capacity to simultaneously activate two reagents towards one another, offer numerous opportunities for the discovery of powerful, asymmetric bond forming reactions. When a compound possesses a combination of Brønsted (or Lewis) basic and Lewis acidic sites, has a well-defined chiral pocket constructed around a fairly rigid skeleton and appropriate distances between the two activating groups, the templating of a pronucleophile (NuH) and an electrophile via a ternary complex can lead to excellent levels of enantio- and diastereocontrol in efficient addition reactions at low catalyst loadings. The design and synthesis of new, readily accessible catalytic systems plays a pivotal role in this field of research allowing the discovery of useful synthetic pathways, rapid optimization of the ligand canopy and a better understanding of the mechanism and origins of stereocontrol. During this Fellowship we wish to develop new and synthetically powerful enantioselective inter- and intramolecular addition reaction of isocyanoacetate pronucleophiles under cooperative base and Lewis acid catalysis. In particular we wish to investigate the addition chemistry of imines and electron deficient double bonds, as well as intramolecular additions to pendant alkyne functionality, using novel aminophosphine precatalyst/transition metal ion combinations. Not only will these reactions constitute important developments in the field but the product structures are often biologically relevant, thus lending the chemistry to important synthetic applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry organic reactions
- natural sciences chemical sciences catalysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.